The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi
Trypanosoma cruzi, the protozoan responsible for Chagas disease, has a complex life cycle comprehending two distinct hosts and a series of morphological and functional transformations. Hemoglobin degradation inside the insect vector releases high amounts of heme, and this molecule is known to exert...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2011/174614 |
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| author | Marcia Cristina Paes Daniela Cosentino-Gomes Cíntia Fernandes de Souza Natália Pereira de Almeida Nogueira José Roberto Meyer-Fernandes |
| author_facet | Marcia Cristina Paes Daniela Cosentino-Gomes Cíntia Fernandes de Souza Natália Pereira de Almeida Nogueira José Roberto Meyer-Fernandes |
| author_sort | Marcia Cristina Paes |
| collection | DOAJ |
| description | Trypanosoma cruzi, the protozoan responsible for Chagas disease, has a complex life cycle comprehending two distinct hosts and a series of morphological and functional transformations. Hemoglobin degradation inside the insect vector releases high amounts of heme, and this molecule is known to exert a number of physiological functions. Moreover, the absence of its complete biosynthetic pathway in T. cruzi indicates heme as an essential molecule for this trypanosomatid survival. Within the hosts, T. cruzi has to cope with sudden environmental changes especially in the redox status and heme is able to increase the basal production of reactive oxygen species (ROS) which can be also produced as byproducts of the parasite aerobic metabolism. In this regard, ROS sensing is likely to be an important mechanism for the adaptation and interaction of these organisms with their hosts. In this paper we discuss the main features of heme and ROS susceptibility in T. cruzi biology. |
| format | Article |
| id | doaj-art-1a80977e03da490db2e9066ff6b353d4 |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-1a80977e03da490db2e9066ff6b353d42025-02-03T01:29:55ZengWileyJournal of Parasitology Research2090-00232090-00312011-01-01201110.1155/2011/174614174614The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruziMarcia Cristina Paes0Daniela Cosentino-Gomes1Cíntia Fernandes de Souza2Natália Pereira de Almeida Nogueira3José Roberto Meyer-Fernandes4Laboratório de Interação de Tripanossomatídeos e Vetores, Departamento de Bioquímica, IBRAG, UERJ, 20521-160 Rio de Janeiro, RJ, BrazilLaboratório de Bioquímica Celular, Instituto de Bioquímica Médica, Centro de Ciências da Saúde, UFRJ, 21941-521 Rio de Janeiro, RJ, BrazilLaboratório de Interação de Tripanossomatídeos e Vetores, Departamento de Bioquímica, IBRAG, UERJ, 20521-160 Rio de Janeiro, RJ, BrazilLaboratório de Interação de Tripanossomatídeos e Vetores, Departamento de Bioquímica, IBRAG, UERJ, 20521-160 Rio de Janeiro, RJ, BrazilLaboratório de Bioquímica Celular, Instituto de Bioquímica Médica, Centro de Ciências da Saúde, UFRJ, 21941-521 Rio de Janeiro, RJ, BrazilTrypanosoma cruzi, the protozoan responsible for Chagas disease, has a complex life cycle comprehending two distinct hosts and a series of morphological and functional transformations. Hemoglobin degradation inside the insect vector releases high amounts of heme, and this molecule is known to exert a number of physiological functions. Moreover, the absence of its complete biosynthetic pathway in T. cruzi indicates heme as an essential molecule for this trypanosomatid survival. Within the hosts, T. cruzi has to cope with sudden environmental changes especially in the redox status and heme is able to increase the basal production of reactive oxygen species (ROS) which can be also produced as byproducts of the parasite aerobic metabolism. In this regard, ROS sensing is likely to be an important mechanism for the adaptation and interaction of these organisms with their hosts. In this paper we discuss the main features of heme and ROS susceptibility in T. cruzi biology.http://dx.doi.org/10.1155/2011/174614 |
| spellingShingle | Marcia Cristina Paes Daniela Cosentino-Gomes Cíntia Fernandes de Souza Natália Pereira de Almeida Nogueira José Roberto Meyer-Fernandes The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi Journal of Parasitology Research |
| title | The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi |
| title_full | The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi |
| title_fullStr | The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi |
| title_full_unstemmed | The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi |
| title_short | The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi |
| title_sort | role of heme and reactive oxygen species in proliferation and survival of trypanosoma cruzi |
| url | http://dx.doi.org/10.1155/2011/174614 |
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