Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway

Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway

Appropriate formation of blood vessels is critical for tendon-bone healing during tendon injury, as excessive angiogenesis would exacerbate scar formation and lead to chronic pain and dysfunction. The mechanism to regulate inflammatory angiogenesis during tendon-bone healing remains to be elucidated...

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Main Authors: Yang Yong, Wang Huajun, Hou Huige, Chen Jiwen, Chen Xiaolei, Zheng Hongjian, Zheng Kai, Ye Baofei, Wu Chunhui, Zheng Xiaofei, Yuan Shiguo, Zheng Boyuan
Format: Article
Language:English
Published: De Gruyter 2025-05-01
Series:Open Medicine
Subjects:
celastrol
neovascularization
angiogenesis
inflammation
tenocytes
nlrp3
rotator cuff tear
Online Access:https://doi.org/10.1515/med-2024-1121
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