Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023–2024
Middle East respiratory syndrome coronavirus (MERS-CoV) circulates in dromedary camels in the Arabian Peninsula and occasionally causes spillover infections in humans. MERS-CoV diversity is poorly understood because of the lack of sampling during the COVID-19 pandemic. We collected 558 swab samples...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2025-01-01
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| Series: | Emerging Infectious Diseases |
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| Online Access: | https://wwwnc.cdc.gov/eid/article/31/1/24-1030_article |
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| author | Ahmed M. Hassan Barbara Mühlemann Tagreed L. Al-Subhi Jordi Rodon Sherif A. El-Kafrawy Ziad Memish Julia Melchert Tobias Bleicker Tiina Mauno Stanley Perlman Alimuddin Zumla Terry C. Jones Marcel A. Müller Victor M. Corman Christian Drosten Esam I. Azhar |
| author_facet | Ahmed M. Hassan Barbara Mühlemann Tagreed L. Al-Subhi Jordi Rodon Sherif A. El-Kafrawy Ziad Memish Julia Melchert Tobias Bleicker Tiina Mauno Stanley Perlman Alimuddin Zumla Terry C. Jones Marcel A. Müller Victor M. Corman Christian Drosten Esam I. Azhar |
| author_sort | Ahmed M. Hassan |
| collection | DOAJ |
| description |
Middle East respiratory syndrome coronavirus (MERS-CoV) circulates in dromedary camels in the Arabian Peninsula and occasionally causes spillover infections in humans. MERS-CoV diversity is poorly understood because of the lack of sampling during the COVID-19 pandemic. We collected 558 swab samples from dromedary camels in Saudi Arabia during November 2023–January 2024. We found 39% were positive for MERS-CoV RNA by reverse transcription PCR. We sequenced 42 MERS-CoVs and 7 human 229E-related coronaviruses from camel swab samples by using high-throughput sequencing. Sequences from both viruses formed monophyletic clades apical to recently available genomes. MERS-CoV sequences were most similar to B5 lineage sequences and harbored unique genetic features, including novel amino acid polymorphisms in the spike protein. Further characterization will be required to understand their effects. MERS-CoV spillover into humans poses considerable public health concerns. Our findings indicate surveillance and phenotypic studies are needed to identify and monitor MERS-CoV pandemic potential.
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| format | Article |
| id | doaj-art-1a77d74f97624e2da53b97251e2a6762 |
| institution | DOAJ |
| issn | 1080-6040 1080-6059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj-art-1a77d74f97624e2da53b97251e2a67622025-08-20T02:39:56ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592025-01-01311576510.3201/eid3101.241030Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023–2024Ahmed M. HassanBarbara MühlemannTagreed L. Al-SubhiJordi RodonSherif A. El-KafrawyZiad MemishJulia MelchertTobias BleickerTiina MaunoStanley PerlmanAlimuddin ZumlaTerry C. JonesMarcel A. MüllerVictor M. CormanChristian DrostenEsam I. Azhar Middle East respiratory syndrome coronavirus (MERS-CoV) circulates in dromedary camels in the Arabian Peninsula and occasionally causes spillover infections in humans. MERS-CoV diversity is poorly understood because of the lack of sampling during the COVID-19 pandemic. We collected 558 swab samples from dromedary camels in Saudi Arabia during November 2023–January 2024. We found 39% were positive for MERS-CoV RNA by reverse transcription PCR. We sequenced 42 MERS-CoVs and 7 human 229E-related coronaviruses from camel swab samples by using high-throughput sequencing. Sequences from both viruses formed monophyletic clades apical to recently available genomes. MERS-CoV sequences were most similar to B5 lineage sequences and harbored unique genetic features, including novel amino acid polymorphisms in the spike protein. Further characterization will be required to understand their effects. MERS-CoV spillover into humans poses considerable public health concerns. Our findings indicate surveillance and phenotypic studies are needed to identify and monitor MERS-CoV pandemic potential. https://wwwnc.cdc.gov/eid/article/31/1/24-1030_articleMiddle East respiratory syndrome coronavirusMERS-CoVcoronaviruscoronavirus diseaseemerging virusesvirology |
| spellingShingle | Ahmed M. Hassan Barbara Mühlemann Tagreed L. Al-Subhi Jordi Rodon Sherif A. El-Kafrawy Ziad Memish Julia Melchert Tobias Bleicker Tiina Mauno Stanley Perlman Alimuddin Zumla Terry C. Jones Marcel A. Müller Victor M. Corman Christian Drosten Esam I. Azhar Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023–2024 Emerging Infectious Diseases Middle East respiratory syndrome coronavirus MERS-CoV coronavirus coronavirus disease emerging viruses virology |
| title | Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023–2024 |
| title_full | Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023–2024 |
| title_fullStr | Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023–2024 |
| title_full_unstemmed | Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023–2024 |
| title_short | Ongoing Evolution of Middle East Respiratory Syndrome Coronavirus, Saudi Arabia, 2023–2024 |
| title_sort | ongoing evolution of middle east respiratory syndrome coronavirus saudi arabia 2023 2024 |
| topic | Middle East respiratory syndrome coronavirus MERS-CoV coronavirus coronavirus disease emerging viruses virology |
| url | https://wwwnc.cdc.gov/eid/article/31/1/24-1030_article |
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