Neuronal hyperexcitability in dystrophin-deficient mdx hippocampal neurons: the importance of interleukin-6 and GABAergic regulation

Neuronal hyperexcitability in dystrophin-deficient mdx hippocampal neurons: the importance of interleukin-6 and GABAergic regulation

Abstract Duchenne Muscular Dystrophy (DMD) is a severe neuromuscular disorder arising from loss of the structural protein, dystrophin. It also often presents with cognitive deficits and susceptibility to epilepsy. Expressed in neurons of the hippocampus, dystrophin plays an important role in synapse...

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Bibliographic Details
Main Authors: Kimberley A. Stephenson, Qiao Xiao, Michael B. Vaughan, Polly Peters, Claire Denley, Sean O’Meara, Cecelia Sheehan, Mark G. Rae, Dervla O’Malley
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Duchenne muscular dystrophy
Dystrophin
Hippocampus
Learning
Memory
GABA
Online Access:https://doi.org/10.1038/s41598-025-00880-z
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