Microalbuminuria and sRAGE in High-Risk Hypertensive Patients Treated with Nifedipine/Telmisartan Combination Treatment: A Substudy of TALENT
Some antihypertensive drugs have also renoprotective and anti-inflammatory properties that go beyond their effect on blood pressure. It has been suggested that microalbuminuria and glomerular filtration rate (GFR) are associated with circulating levels of the soluble form of the receptor, sRAGE (sol...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/874149 |
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| author | Colomba Falcone Maria Paola Buzzi Sara Bozzini Chiara Boiocchi Angela D'Angelo Sandra Schirinzi Ciro Esposito Massimo Torreggiani Jasmine Choi Michael Ochan Kilama Giuseppe Mancia |
| author_facet | Colomba Falcone Maria Paola Buzzi Sara Bozzini Chiara Boiocchi Angela D'Angelo Sandra Schirinzi Ciro Esposito Massimo Torreggiani Jasmine Choi Michael Ochan Kilama Giuseppe Mancia |
| author_sort | Colomba Falcone |
| collection | DOAJ |
| description | Some antihypertensive drugs have also renoprotective and anti-inflammatory properties that go beyond their effect on blood pressure. It has been suggested that microalbuminuria and glomerular filtration rate (GFR) are associated with circulating levels of the soluble form of the receptor, sRAGE (soluble receptor for advanced glycation ends-products). In the present analysis, we used data from the TALENT study to evaluate soluble receptor for advanced glycation end-products (sRAGE) plasma levels in patients with hypertension and high-cardiovascular risk-treated nifedipine and telmisartan in combination. Treatment with nifedipine-telmisartan significantly decreased mean systolic and diastolic ambulatory blood pressure and resulted in a significant increase in sRAGE plasma concentrations after 24 weeks of therapy. We concluded that in hypertensive patients with early-stage renal disease, sRAGE concentrations are not influenced by either microalbuminuria or GFR. Long-term treatment with a combination of nifedipine-telmisartan may have a beneficial effect increasing sRAGE plasma levels, thus exerting an atheroprotective and anti-inflammatory activity. |
| format | Article |
| id | doaj-art-1a6fcb14f57c4a26afe8d552036fae65 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1a6fcb14f57c4a26afe8d552036fae652025-02-03T01:09:09ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/874149874149Microalbuminuria and sRAGE in High-Risk Hypertensive Patients Treated with Nifedipine/Telmisartan Combination Treatment: A Substudy of TALENTColomba Falcone0Maria Paola Buzzi1Sara Bozzini2Chiara Boiocchi3Angela D'Angelo4Sandra Schirinzi5Ciro Esposito6Massimo Torreggiani7Jasmine Choi8Michael Ochan Kilama9Giuseppe Mancia10Interdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyInterdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyInterdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyInterdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyInterdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, 27100 Pavia, ItalyDepartment of Cardiology, Istituto di Cura Città di Pavia, University Hospital, 27100 Pavia, ItalyDepartment of Nephrology, IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, ItalyDepartment of Nephrology, IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, ItalyScientific Relations, Medical Department, Bayer S.p.A-Pharmaceutical, 20156 Milan, ItalyScientific Relations, Medical Department, Bayer S.p.A-Pharmaceutical, 20156 Milan, ItalyDepartment of Clinical Medicine and Prevention, University of Milano-Bicocca, 20126 Milan, ItalySome antihypertensive drugs have also renoprotective and anti-inflammatory properties that go beyond their effect on blood pressure. It has been suggested that microalbuminuria and glomerular filtration rate (GFR) are associated with circulating levels of the soluble form of the receptor, sRAGE (soluble receptor for advanced glycation ends-products). In the present analysis, we used data from the TALENT study to evaluate soluble receptor for advanced glycation end-products (sRAGE) plasma levels in patients with hypertension and high-cardiovascular risk-treated nifedipine and telmisartan in combination. Treatment with nifedipine-telmisartan significantly decreased mean systolic and diastolic ambulatory blood pressure and resulted in a significant increase in sRAGE plasma concentrations after 24 weeks of therapy. We concluded that in hypertensive patients with early-stage renal disease, sRAGE concentrations are not influenced by either microalbuminuria or GFR. Long-term treatment with a combination of nifedipine-telmisartan may have a beneficial effect increasing sRAGE plasma levels, thus exerting an atheroprotective and anti-inflammatory activity.http://dx.doi.org/10.1155/2012/874149 |
| spellingShingle | Colomba Falcone Maria Paola Buzzi Sara Bozzini Chiara Boiocchi Angela D'Angelo Sandra Schirinzi Ciro Esposito Massimo Torreggiani Jasmine Choi Michael Ochan Kilama Giuseppe Mancia Microalbuminuria and sRAGE in High-Risk Hypertensive Patients Treated with Nifedipine/Telmisartan Combination Treatment: A Substudy of TALENT Mediators of Inflammation |
| title | Microalbuminuria and sRAGE in High-Risk Hypertensive Patients Treated with Nifedipine/Telmisartan Combination Treatment: A Substudy of TALENT |
| title_full | Microalbuminuria and sRAGE in High-Risk Hypertensive Patients Treated with Nifedipine/Telmisartan Combination Treatment: A Substudy of TALENT |
| title_fullStr | Microalbuminuria and sRAGE in High-Risk Hypertensive Patients Treated with Nifedipine/Telmisartan Combination Treatment: A Substudy of TALENT |
| title_full_unstemmed | Microalbuminuria and sRAGE in High-Risk Hypertensive Patients Treated with Nifedipine/Telmisartan Combination Treatment: A Substudy of TALENT |
| title_short | Microalbuminuria and sRAGE in High-Risk Hypertensive Patients Treated with Nifedipine/Telmisartan Combination Treatment: A Substudy of TALENT |
| title_sort | microalbuminuria and srage in high risk hypertensive patients treated with nifedipine telmisartan combination treatment a substudy of talent |
| url | http://dx.doi.org/10.1155/2012/874149 |
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