Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population
Background. Levels of the protein kinase aPKC have been previously correlated with prostate cancer prognosis in a British cohort. However, prostate cancer incidence and progression rates, as well as genetic changes in this disease, show strong ethnic variance, particularly in Asian populations. Obje...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2014/481697 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567779088138240 |
|---|---|
| author | Anthony S. Perry Bungo Furusato Raymond B. Nagle Sourav Ghosh |
| author_facet | Anthony S. Perry Bungo Furusato Raymond B. Nagle Sourav Ghosh |
| author_sort | Anthony S. Perry |
| collection | DOAJ |
| description | Background. Levels of the protein kinase aPKC have been previously correlated with prostate cancer prognosis in a British cohort. However, prostate cancer incidence and progression rates, as well as genetic changes in this disease, show strong ethnic variance, particularly in Asian populations. Objective. The aim of this study was to validate association of aPKC expression with prostatic adenocarcinoma stages in a Japanese cohort. Methods. Tissue microarrays consisting of 142 malignant prostate cancer cases and 21 benign prostate tissues were subject to immunohistological staining for aPKC. aPKC staining intensity was scored by three independent pathologists and categorized as absent (0), dim (1+), intermediate (2+), and bright (3+). aPKC staining intensities were correlated with Gleason score and tumor stage. Results. Increased aPKC staining was observed in malignant prostate cancer, in comparison to benign tissue. Additionally, aPKC staining levels correlated with Gleason score and tumor stage. Our results extend the association of aPKC with prostate cancer to a Japanese population and establish the suitability of aPKC as a universal prostate cancer biomarker that performs consistently across ethnicities. |
| format | Article |
| id | doaj-art-1a68bd2394a94c71ab22a6a553359795 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-1a68bd2394a94c71ab22a6a5533597952025-02-03T01:00:26ZengWileyProstate Cancer2090-31112090-312X2014-01-01201410.1155/2014/481697481697Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese PopulationAnthony S. Perry0Bungo Furusato1Raymond B. Nagle2Sourav Ghosh3Department of Pathology, Banner MD Anderson Cancer Center, Gilbert, AZ 85234, USADepartment of Pathology, Jikei University School of Medicine, Tokyo 105-8461, JapanDepartment of Pathology, The University of Arizona and Arizona Cancer Center, Tucson, AZ 85724-5044, USADepartment of Cellular & Molecular Medicine, The University of Arizona and Arizona Cancer Center, Tucson, AZ 85724-5044, USABackground. Levels of the protein kinase aPKC have been previously correlated with prostate cancer prognosis in a British cohort. However, prostate cancer incidence and progression rates, as well as genetic changes in this disease, show strong ethnic variance, particularly in Asian populations. Objective. The aim of this study was to validate association of aPKC expression with prostatic adenocarcinoma stages in a Japanese cohort. Methods. Tissue microarrays consisting of 142 malignant prostate cancer cases and 21 benign prostate tissues were subject to immunohistological staining for aPKC. aPKC staining intensity was scored by three independent pathologists and categorized as absent (0), dim (1+), intermediate (2+), and bright (3+). aPKC staining intensities were correlated with Gleason score and tumor stage. Results. Increased aPKC staining was observed in malignant prostate cancer, in comparison to benign tissue. Additionally, aPKC staining levels correlated with Gleason score and tumor stage. Our results extend the association of aPKC with prostate cancer to a Japanese population and establish the suitability of aPKC as a universal prostate cancer biomarker that performs consistently across ethnicities.http://dx.doi.org/10.1155/2014/481697 |
| spellingShingle | Anthony S. Perry Bungo Furusato Raymond B. Nagle Sourav Ghosh Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population Prostate Cancer |
| title | Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population |
| title_full | Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population |
| title_fullStr | Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population |
| title_full_unstemmed | Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population |
| title_short | Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population |
| title_sort | increased apkc expression correlates with prostatic adenocarcinoma gleason score and tumor stage in the japanese population |
| url | http://dx.doi.org/10.1155/2014/481697 |
| work_keys_str_mv | AT anthonysperry increasedapkcexpressioncorrelateswithprostaticadenocarcinomagleasonscoreandtumorstageinthejapanesepopulation AT bungofurusato increasedapkcexpressioncorrelateswithprostaticadenocarcinomagleasonscoreandtumorstageinthejapanesepopulation AT raymondbnagle increasedapkcexpressioncorrelateswithprostaticadenocarcinomagleasonscoreandtumorstageinthejapanesepopulation AT souravghosh increasedapkcexpressioncorrelateswithprostaticadenocarcinomagleasonscoreandtumorstageinthejapanesepopulation |