Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease
Background. Midkine (MK), a new heparin-binding growth factor, plays important roles in a variety of biological phenomena such as carcinogenesis, inflammation, and angiogenesis. In this study, we aimed to evaluate serum midkine (SMK) and nodular midkine (NMK) levels in patients with thyroid nodules...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/6035024 |
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| author | Fatih Kuzu Dilek Arpaci Mustafa Unal Ayfer Altas Gürkan Haytaoglu Murat Can Figen Barut Furuzan Kokturk Sevil Uygun Ilikhan Taner Bayraktaroglu |
| author_facet | Fatih Kuzu Dilek Arpaci Mustafa Unal Ayfer Altas Gürkan Haytaoglu Murat Can Figen Barut Furuzan Kokturk Sevil Uygun Ilikhan Taner Bayraktaroglu |
| author_sort | Fatih Kuzu |
| collection | DOAJ |
| description | Background. Midkine (MK), a new heparin-binding growth factor, plays important roles in a variety of biological phenomena such as carcinogenesis, inflammation, and angiogenesis. In this study, we aimed to evaluate serum midkine (SMK) and nodular midkine (NMK) levels in patients with thyroid nodules to predict malignancy and whether there was any association between. Methods. A total of 105 patients (74 women, 31 men) with thyroid nodules were enrolled. The levels of SMK and NMK were measured. Any possible correlation between SMK, NMK, and biochemical, cytopathological, or radiological variables was investigated. Results. Both SMK and NMK were found to be higher in hypoechoic nodules with an irregular border and without a halo (p<0.05). Serum MK levels were significantly higher in nodules with microcalcifications than nodules with macrocalcification or without calcification (p=0.001). SMK levels were found to be correlated with NMK levels (SMK 0.63 ng/ml versus 1.04 ng/mL and NMK 0.55 ng/mL versus 0.55 ng/mL, r2=0.54, p<0.001). Conclusion. Both SMK and NMK can predict tumorigenesis of highly malignant/suspicious thyroid cytopathology and also well correlated with sonographic features of thyroid nodules. We suggest that MK levels may serve as an alternative biomarker, in conjunction with the cytopathological results in preoperative assessment of thyroid nodules. |
| format | Article |
| id | doaj-art-1a622e36f46e4a548b475e956def4030 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1a622e36f46e4a548b475e956def40302025-02-03T00:59:11ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/60350246035024Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid DiseaseFatih Kuzu0Dilek Arpaci1Mustafa Unal2Ayfer Altas3Gürkan Haytaoglu4Murat Can5Figen Barut6Furuzan Kokturk7Sevil Uygun Ilikhan8Taner Bayraktaroglu9Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyDepartment of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyDepartment of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyDepartment of Biochemistry, Faculty of Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyDepartment of Pathology, Faculty of Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyDepartment of Biostatistics, Faculty of Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyDepartment of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Bulent Ecevit University, 67600 Zonguldak, TurkeyBackground. Midkine (MK), a new heparin-binding growth factor, plays important roles in a variety of biological phenomena such as carcinogenesis, inflammation, and angiogenesis. In this study, we aimed to evaluate serum midkine (SMK) and nodular midkine (NMK) levels in patients with thyroid nodules to predict malignancy and whether there was any association between. Methods. A total of 105 patients (74 women, 31 men) with thyroid nodules were enrolled. The levels of SMK and NMK were measured. Any possible correlation between SMK, NMK, and biochemical, cytopathological, or radiological variables was investigated. Results. Both SMK and NMK were found to be higher in hypoechoic nodules with an irregular border and without a halo (p<0.05). Serum MK levels were significantly higher in nodules with microcalcifications than nodules with macrocalcification or without calcification (p=0.001). SMK levels were found to be correlated with NMK levels (SMK 0.63 ng/ml versus 1.04 ng/mL and NMK 0.55 ng/mL versus 0.55 ng/mL, r2=0.54, p<0.001). Conclusion. Both SMK and NMK can predict tumorigenesis of highly malignant/suspicious thyroid cytopathology and also well correlated with sonographic features of thyroid nodules. We suggest that MK levels may serve as an alternative biomarker, in conjunction with the cytopathological results in preoperative assessment of thyroid nodules.http://dx.doi.org/10.1155/2016/6035024 |
| spellingShingle | Fatih Kuzu Dilek Arpaci Mustafa Unal Ayfer Altas Gürkan Haytaoglu Murat Can Figen Barut Furuzan Kokturk Sevil Uygun Ilikhan Taner Bayraktaroglu Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease International Journal of Endocrinology |
| title | Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease |
| title_full | Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease |
| title_fullStr | Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease |
| title_full_unstemmed | Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease |
| title_short | Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease |
| title_sort | midkine a novel biomarker to predict malignancy in patients with nodular thyroid disease |
| url | http://dx.doi.org/10.1155/2016/6035024 |
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