The venom of Cyriopagopus schmidti spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential

The venom of Cyriopagopus schmidti spider contains a natural huwentoxin-IV analogue with unexpected improved analgesic potential

The venom of Cyriopagopus schmidti spider has been extensively investigated, thereby allowing the identification of numerous new natural peptides. Many of these peptides are active on ion channels and several of them occur from post-translational processing. In order to further identify new entities...

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Bibliographic Details
Main Authors: Aurélie Antunes, Jérôme Montnach, Kuldip Khakh, Ludivine Lopez, Baptiste Thomas, Barbara Ribeiro Oliveira-Mendes, Lucie Jaquillard, Denis Servent, Rémy Béroud, Charles J. Cohen, Evelyne Benoit, Michel De Waard
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
spider venom peptide
huwentoxin-IV
Nav1.7
pain treatment
dorsal root ganglion neuron
SAR study
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1566312/full
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