Error-driven upregulation of memory representations
Abstract Learning an association does not always succeed on the first attempt. Previous studies associated increased error signals in posterior medial frontal cortex with improved memory formation. However, the neurophysiological mechanisms that facilitate post-error learning remain poorly understoo...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Communications Psychology |
| Online Access: | https://doi.org/10.1038/s44271-025-00199-5 |
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| _version_ | 1832571285337538560 |
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| author | Alexander Weuthen Hans Kirschner Markus Ullsperger |
| author_facet | Alexander Weuthen Hans Kirschner Markus Ullsperger |
| author_sort | Alexander Weuthen |
| collection | DOAJ |
| description | Abstract Learning an association does not always succeed on the first attempt. Previous studies associated increased error signals in posterior medial frontal cortex with improved memory formation. However, the neurophysiological mechanisms that facilitate post-error learning remain poorly understood. To address this gap, participants performed a feedback-based association learning task and a 1-back localizer task. Increased hemodynamic responses in posterior medial frontal cortex were found for internal and external origins of memory error evidence, and during post-error encoding success as quantified by subsequent recall of face-associated memories. A localizer-based machine learning model displayed a network of cognitive control regions, including posterior medial frontal and dorsolateral prefrontal cortices, whose activity was related to face-processing evidence in the fusiform face area. Representation strength was higher during failed recall and increased during encoding when subsequent recall succeeded. These data enhance our understanding of the neurophysiological mechanisms of adaptive learning by linking the need for learning with increased processing of the relevant stimulus category. |
| format | Article |
| id | doaj-art-1a5a49fc478a40ceb545882ced2a0892 |
| institution | Kabale University |
| issn | 2731-9121 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Psychology |
| spelling | doaj-art-1a5a49fc478a40ceb545882ced2a08922025-02-02T12:41:25ZengNature PortfolioCommunications Psychology2731-91212025-01-013111310.1038/s44271-025-00199-5Error-driven upregulation of memory representationsAlexander Weuthen0Hans Kirschner1Markus Ullsperger2Institute of Psychology, Otto-von-Guericke-University MagdeburgInstitute of Psychology, Otto-von-Guericke-University MagdeburgInstitute of Psychology, Otto-von-Guericke-University MagdeburgAbstract Learning an association does not always succeed on the first attempt. Previous studies associated increased error signals in posterior medial frontal cortex with improved memory formation. However, the neurophysiological mechanisms that facilitate post-error learning remain poorly understood. To address this gap, participants performed a feedback-based association learning task and a 1-back localizer task. Increased hemodynamic responses in posterior medial frontal cortex were found for internal and external origins of memory error evidence, and during post-error encoding success as quantified by subsequent recall of face-associated memories. A localizer-based machine learning model displayed a network of cognitive control regions, including posterior medial frontal and dorsolateral prefrontal cortices, whose activity was related to face-processing evidence in the fusiform face area. Representation strength was higher during failed recall and increased during encoding when subsequent recall succeeded. These data enhance our understanding of the neurophysiological mechanisms of adaptive learning by linking the need for learning with increased processing of the relevant stimulus category.https://doi.org/10.1038/s44271-025-00199-5 |
| spellingShingle | Alexander Weuthen Hans Kirschner Markus Ullsperger Error-driven upregulation of memory representations Communications Psychology |
| title | Error-driven upregulation of memory representations |
| title_full | Error-driven upregulation of memory representations |
| title_fullStr | Error-driven upregulation of memory representations |
| title_full_unstemmed | Error-driven upregulation of memory representations |
| title_short | Error-driven upregulation of memory representations |
| title_sort | error driven upregulation of memory representations |
| url | https://doi.org/10.1038/s44271-025-00199-5 |
| work_keys_str_mv | AT alexanderweuthen errordrivenupregulationofmemoryrepresentations AT hanskirschner errordrivenupregulationofmemoryrepresentations AT markusullsperger errordrivenupregulationofmemoryrepresentations |