BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity

BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity

Summary: Trained immunity refers to memory-like responses of innate immune cells when they re-encounter pathogenic stimuli. Bacillus Calmette-Guérin (BCG) vaccination implies enhanced antiviral immunity, whereas the underlying mechanisms remain unclear. Herein, we have uncovered elevated expression...

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Main Authors: Yangdian Lai, Xiaoxu Yang, Dong Wei, Xin Wang, Ruiming Sun, Yunfei Li, Ping Ji, Yujie Bao, Tiancheng Chu, Chenxing Zhang, Qiming Liang, Jie Xu, Xinxin Zhang, Yingying Chen, Ying Wang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725002645
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