Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorder
Abstract Background Previous studies showed sex differences in the prevalences of both major depressive disorder (MDD) and subclinical hypothyroidism (SCH). This study aimed to further compare the prevalence and correlates of moderate-to-severe SCH between male and female Chinese MDD patients. Metho...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12888-024-06244-7 |
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| author | Junqiang Cui Yujia Weng XiaoE Lang Fangfang Shangguan Xiang-Yang Zhang |
| author_facet | Junqiang Cui Yujia Weng XiaoE Lang Fangfang Shangguan Xiang-Yang Zhang |
| author_sort | Junqiang Cui |
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| description | Abstract Background Previous studies showed sex differences in the prevalences of both major depressive disorder (MDD) and subclinical hypothyroidism (SCH). This study aimed to further compare the prevalence and correlates of moderate-to-severe SCH between male and female Chinese MDD patients. Methods A total of 1706 first-episode drug naïve Chinese patients with MDD were recruited. Depressive symptoms were assessed by the 17-item Hamilton Depression Rating Scale, psychotic symptoms by the Positive and Negative Syndrome Scale and anxiety symptoms by the Hamilton Anxiety Rating Scale. Serum thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) concentrations were measured by chemiluminescence immunoassay. Moderate-to-severe SCH was defined as serum TSH > 8 mIU/L with normal fT4. Results The prevalence of moderate-to-severe SCH was 10.4% in male patients and 15.1% in female patients (χ2 = 7.22, p < 0.01). In female patients, binary logistic regression showed that systolic blood pressure (SBP), suicide attempts and psychotic symptoms (all p < 0.001) were associated with moderate-to-severe SCH. In male patients, SBP and psychotic symptoms were associated with moderate-to-severe SCH (both p < 0.001), while suicide attempts and severe anxiety were not (p > 0.05). Conclusions Our findings reveal a higher prevalence rate of moderate-to-severe SCH in female untreated first-episode MDD patients compared with males. Moreover, there is a positive association between suicide attempts and moderate-to-severe SCH only in female MDD patients. |
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| id | doaj-art-1a5611bdbf824483b58fa35f678ccc8a |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Psychiatry |
| spelling | doaj-art-1a5611bdbf824483b58fa35f678ccc8a2025-01-26T12:46:42ZengBMCBMC Psychiatry1471-244X2025-01-0125111010.1186/s12888-024-06244-7Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorderJunqiang Cui0Yujia Weng1XiaoE Lang2Fangfang Shangguan3Xiang-Yang Zhang4Department of Psychiatry, Shanxi Children’s Hospital, Shanxi Maternal and Child Health HospitalSchool of Psychology, Capital Normal UniversityDepartment of Psychiatry, The First Clinical Medical College, Shanxi Medical UniversitySchool of Psychology, Capital Normal UniversityHefei Fourth Peoples Hospital; Anhui Mental Health CenterAbstract Background Previous studies showed sex differences in the prevalences of both major depressive disorder (MDD) and subclinical hypothyroidism (SCH). This study aimed to further compare the prevalence and correlates of moderate-to-severe SCH between male and female Chinese MDD patients. Methods A total of 1706 first-episode drug naïve Chinese patients with MDD were recruited. Depressive symptoms were assessed by the 17-item Hamilton Depression Rating Scale, psychotic symptoms by the Positive and Negative Syndrome Scale and anxiety symptoms by the Hamilton Anxiety Rating Scale. Serum thyroid stimulating hormone (TSH), free triiodothyronine (fT3) and free thyroxine (fT4) concentrations were measured by chemiluminescence immunoassay. Moderate-to-severe SCH was defined as serum TSH > 8 mIU/L with normal fT4. Results The prevalence of moderate-to-severe SCH was 10.4% in male patients and 15.1% in female patients (χ2 = 7.22, p < 0.01). In female patients, binary logistic regression showed that systolic blood pressure (SBP), suicide attempts and psychotic symptoms (all p < 0.001) were associated with moderate-to-severe SCH. In male patients, SBP and psychotic symptoms were associated with moderate-to-severe SCH (both p < 0.001), while suicide attempts and severe anxiety were not (p > 0.05). Conclusions Our findings reveal a higher prevalence rate of moderate-to-severe SCH in female untreated first-episode MDD patients compared with males. Moreover, there is a positive association between suicide attempts and moderate-to-severe SCH only in female MDD patients.https://doi.org/10.1186/s12888-024-06244-7Major depressive disorderSubclinical hypothyroidismThyroid stimulating hormoneAnxietySuicidal behavior |
| spellingShingle | Junqiang Cui Yujia Weng XiaoE Lang Fangfang Shangguan Xiang-Yang Zhang Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorder BMC Psychiatry Major depressive disorder Subclinical hypothyroidism Thyroid stimulating hormone Anxiety Suicidal behavior |
| title | Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorder |
| title_full | Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorder |
| title_fullStr | Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorder |
| title_full_unstemmed | Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorder |
| title_short | Sex differences in prevalence and clinical correlates of subclinical hypothyroidism in Chinese patients with first-episode untreated major depressive disorder |
| title_sort | sex differences in prevalence and clinical correlates of subclinical hypothyroidism in chinese patients with first episode untreated major depressive disorder |
| topic | Major depressive disorder Subclinical hypothyroidism Thyroid stimulating hormone Anxiety Suicidal behavior |
| url | https://doi.org/10.1186/s12888-024-06244-7 |
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