Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis
Sepsis, frequently caused by infection of bacteria, is considered as an uncontrollable systematic inflammation response syndrome (SIRS). Maresin 1 (Mar1) is a new proresolving mediator with potent anti-inflammatory effect in several animal models. However, its effect in sepsis is still not investiga...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/3798465 |
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| author | Ruidong Li Yaxin Wang Zhijun Ma Muyuan Ma Di Wang Gengchen Xie Yuping Yin Peng Zhang Kaixiong Tao |
| author_facet | Ruidong Li Yaxin Wang Zhijun Ma Muyuan Ma Di Wang Gengchen Xie Yuping Yin Peng Zhang Kaixiong Tao |
| author_sort | Ruidong Li |
| collection | DOAJ |
| description | Sepsis, frequently caused by infection of bacteria, is considered as an uncontrollable systematic inflammation response syndrome (SIRS). Maresin 1 (Mar1) is a new proresolving mediator with potent anti-inflammatory effect in several animal models. However, its effect in sepsis is still not investigated. To address this question, we developed sepsis model in BALB/c mice by cecal ligation and puncture (CLP) with or without Mar1 treatment. Our data showed that Mar1 markedly improved survival rate and decreased the levels of proinflammatory cytokines in CLP mice such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). Furthermore, Mar1 reduced serum level of lipopolysaccharide (LPS) and enhanced the bacteria clearance in mice sepsis model. Moreover, Mar1 attenuated lung injury and decreased level of alanine transaminase (ALT), aspartate transaminase (AST), creatinine (Cre), and blood urea nitrogen (BUN) in serum in mice after CLP surgery. Treatment with Mar1 inhibited activation of nuclear factor kappa B (NF-κb) pathway. In conclusion, Mar1 exhibited protective effect in sepsis by reducing LPS, bacteria burden in serum, inhibiting inflammation response, and improving vital organ function. The possible mechanism is partly involved in inhibition of NF-κb activation. |
| format | Article |
| id | doaj-art-1a547b08cb3643958ff130e662a9ac45 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1a547b08cb3643958ff130e662a9ac452025-02-03T01:26:12ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/37984653798465Maresin 1 Mitigates Inflammatory Response and Protects Mice from SepsisRuidong Li0Yaxin Wang1Zhijun Ma2Muyuan Ma3Di Wang4Gengchen Xie5Yuping Yin6Peng Zhang7Kaixiong Tao8Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan 430022, ChinaDepartment of Anesthesiology and Critical Care, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan 430022, ChinaDepartment of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan 430022, ChinaDepartment of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan 430022, ChinaDepartment of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan 430022, ChinaDepartment of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan 430022, ChinaDepartment of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan 430022, ChinaDepartment of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan 430022, ChinaDepartment of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Ave, Wuhan 430022, ChinaSepsis, frequently caused by infection of bacteria, is considered as an uncontrollable systematic inflammation response syndrome (SIRS). Maresin 1 (Mar1) is a new proresolving mediator with potent anti-inflammatory effect in several animal models. However, its effect in sepsis is still not investigated. To address this question, we developed sepsis model in BALB/c mice by cecal ligation and puncture (CLP) with or without Mar1 treatment. Our data showed that Mar1 markedly improved survival rate and decreased the levels of proinflammatory cytokines in CLP mice such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). Furthermore, Mar1 reduced serum level of lipopolysaccharide (LPS) and enhanced the bacteria clearance in mice sepsis model. Moreover, Mar1 attenuated lung injury and decreased level of alanine transaminase (ALT), aspartate transaminase (AST), creatinine (Cre), and blood urea nitrogen (BUN) in serum in mice after CLP surgery. Treatment with Mar1 inhibited activation of nuclear factor kappa B (NF-κb) pathway. In conclusion, Mar1 exhibited protective effect in sepsis by reducing LPS, bacteria burden in serum, inhibiting inflammation response, and improving vital organ function. The possible mechanism is partly involved in inhibition of NF-κb activation.http://dx.doi.org/10.1155/2016/3798465 |
| spellingShingle | Ruidong Li Yaxin Wang Zhijun Ma Muyuan Ma Di Wang Gengchen Xie Yuping Yin Peng Zhang Kaixiong Tao Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis Mediators of Inflammation |
| title | Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis |
| title_full | Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis |
| title_fullStr | Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis |
| title_full_unstemmed | Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis |
| title_short | Maresin 1 Mitigates Inflammatory Response and Protects Mice from Sepsis |
| title_sort | maresin 1 mitigates inflammatory response and protects mice from sepsis |
| url | http://dx.doi.org/10.1155/2016/3798465 |
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