Pulmonary Kaposi Sarcoma: An Uncommon Cause of Respiratory Failure in the Era of Highly Active Antiretroviral Therapy—Case Report and Review of the Literature
Kaposi Sarcoma (KS) is the most common malignancy associated with Acquired Immune Deficiency Syndrome (AIDS) and is caused by Human Herpesvirus 8 (HHV 8) or Kaposi Sarcoma Herpesvirus (KSHV). In about 90% of cases Kaposi Sarcoma is associated with cutaneous lesions; however visceral disease can occu...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2016/9354136 |
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| author | Stanley M. Nwabudike Stefan Hemmings Yonette Paul Yordanis Habtegebriel Octavius Polk Alem Mehari |
| author_facet | Stanley M. Nwabudike Stefan Hemmings Yonette Paul Yordanis Habtegebriel Octavius Polk Alem Mehari |
| author_sort | Stanley M. Nwabudike |
| collection | DOAJ |
| description | Kaposi Sarcoma (KS) is the most common malignancy associated with Acquired Immune Deficiency Syndrome (AIDS) and is caused by Human Herpesvirus 8 (HHV 8) or Kaposi Sarcoma Herpesvirus (KSHV). In about 90% of cases Kaposi Sarcoma is associated with cutaneous lesions; however visceral disease can occur in the absence of cutaneous involvement. In the era of Highly Active Antiretroviral Therapy (HAART), the incidence of KS has declined. Clinical features of pulmonary KS might be difficult to distinguish from pneumonia in the immunocompromised patients and could lead to diagnostic challenges. First-line treatment of KS is with HAART and the incidence has declined with its use. Systemic chemotherapy may play a role depending on the extent of the disease. We report the case of a young man who presented with pulmonary symptoms and was later found to have pulmonary KS. Interestingly this diagnosis was made in the absence of the classic skin lesions. His disease was complicated by progressive respiratory failure and he eventually died. |
| format | Article |
| id | doaj-art-1a538978dc69401dac7aa7494f506b69 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-1a538978dc69401dac7aa7494f506b692025-02-03T06:05:20ZengWileyCase Reports in Infectious Diseases2090-66252090-66332016-01-01201610.1155/2016/93541369354136Pulmonary Kaposi Sarcoma: An Uncommon Cause of Respiratory Failure in the Era of Highly Active Antiretroviral Therapy—Case Report and Review of the LiteratureStanley M. Nwabudike0Stefan Hemmings1Yonette Paul2Yordanis Habtegebriel3Octavius Polk4Alem Mehari5Department of Internal Medicine, Howard University College of Medicine, Washington, DC, USADepartment of Internal Medicine, Howard University College of Medicine, Washington, DC, USADepartment of Internal Medicine, Howard University College of Medicine, Washington, DC, USADivision of Pulmonary and Critical Care, Howard University College of Medicine, Washington, DC, USADivision of Pulmonary and Critical Care, Howard University College of Medicine, Washington, DC, USADivision of Pulmonary and Critical Care, Howard University College of Medicine, Washington, DC, USAKaposi Sarcoma (KS) is the most common malignancy associated with Acquired Immune Deficiency Syndrome (AIDS) and is caused by Human Herpesvirus 8 (HHV 8) or Kaposi Sarcoma Herpesvirus (KSHV). In about 90% of cases Kaposi Sarcoma is associated with cutaneous lesions; however visceral disease can occur in the absence of cutaneous involvement. In the era of Highly Active Antiretroviral Therapy (HAART), the incidence of KS has declined. Clinical features of pulmonary KS might be difficult to distinguish from pneumonia in the immunocompromised patients and could lead to diagnostic challenges. First-line treatment of KS is with HAART and the incidence has declined with its use. Systemic chemotherapy may play a role depending on the extent of the disease. We report the case of a young man who presented with pulmonary symptoms and was later found to have pulmonary KS. Interestingly this diagnosis was made in the absence of the classic skin lesions. His disease was complicated by progressive respiratory failure and he eventually died.http://dx.doi.org/10.1155/2016/9354136 |
| spellingShingle | Stanley M. Nwabudike Stefan Hemmings Yonette Paul Yordanis Habtegebriel Octavius Polk Alem Mehari Pulmonary Kaposi Sarcoma: An Uncommon Cause of Respiratory Failure in the Era of Highly Active Antiretroviral Therapy—Case Report and Review of the Literature Case Reports in Infectious Diseases |
| title | Pulmonary Kaposi Sarcoma: An Uncommon Cause of Respiratory Failure in the Era of Highly Active Antiretroviral Therapy—Case Report and Review of the Literature |
| title_full | Pulmonary Kaposi Sarcoma: An Uncommon Cause of Respiratory Failure in the Era of Highly Active Antiretroviral Therapy—Case Report and Review of the Literature |
| title_fullStr | Pulmonary Kaposi Sarcoma: An Uncommon Cause of Respiratory Failure in the Era of Highly Active Antiretroviral Therapy—Case Report and Review of the Literature |
| title_full_unstemmed | Pulmonary Kaposi Sarcoma: An Uncommon Cause of Respiratory Failure in the Era of Highly Active Antiretroviral Therapy—Case Report and Review of the Literature |
| title_short | Pulmonary Kaposi Sarcoma: An Uncommon Cause of Respiratory Failure in the Era of Highly Active Antiretroviral Therapy—Case Report and Review of the Literature |
| title_sort | pulmonary kaposi sarcoma an uncommon cause of respiratory failure in the era of highly active antiretroviral therapy case report and review of the literature |
| url | http://dx.doi.org/10.1155/2016/9354136 |
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