Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area
Background. To describe the clinical characteristics of the patients who suffered from relapse after conventional irradiation for nasopharyngeal carcinoma (NPC). Methods. Three hundred and fifty-one consecutive patients with first-time recurrent NPC between January 1999 and July 2005 were included....
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/719754 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545558066102272 |
|---|---|
| author | Jia-Xin Li Tai-Xiang Lu Ying Huang Fei Han |
| author_facet | Jia-Xin Li Tai-Xiang Lu Ying Huang Fei Han |
| author_sort | Jia-Xin Li |
| collection | DOAJ |
| description | Background. To describe the clinical characteristics of the patients who suffered from relapse after conventional irradiation for nasopharyngeal carcinoma (NPC). Methods. Three hundred and fifty-one consecutive patients with first-time recurrent NPC between January 1999 and July 2005 were included. The patients’ clinical data were reviewed, including recurrent interval time, symptoms, signs, imaging characteristics, pathologic features, and restaging. Results. The median interval of relapse was 26.0 months. The most common symptoms in symptomatic patients were nasal bloody discharge (37.9%) and headache (31.1%). Local recurrence alone accounted for 73.5%. Most patients were restaged as stage III (23.1%) and stage IV (51.1%). Subgroup analysis suggested a significantly higher proportion of the long-latent relapses originated from early primary. A series of postreirradiation complications were more frequent in patients with longer latency at reception. Conclusions. Most recurrent nasopharyngeal carcinoma is advanced disease. Patients with different recurrent interval time show different nature behavior. |
| format | Article |
| id | doaj-art-1a4fd6560857447d830a440a5776a38c |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1a4fd6560857447d830a440a5776a38c2025-02-03T07:25:20ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/719754719754Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence AreaJia-Xin Li0Tai-Xiang Lu1Ying Huang2Fei Han3State Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou 510060, ChinaState Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou 510060, ChinaState Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou 510060, ChinaState Key Laboratory of Oncology in South China, Sun Yat-Sen University, Guangzhou 510060, ChinaBackground. To describe the clinical characteristics of the patients who suffered from relapse after conventional irradiation for nasopharyngeal carcinoma (NPC). Methods. Three hundred and fifty-one consecutive patients with first-time recurrent NPC between January 1999 and July 2005 were included. The patients’ clinical data were reviewed, including recurrent interval time, symptoms, signs, imaging characteristics, pathologic features, and restaging. Results. The median interval of relapse was 26.0 months. The most common symptoms in symptomatic patients were nasal bloody discharge (37.9%) and headache (31.1%). Local recurrence alone accounted for 73.5%. Most patients were restaged as stage III (23.1%) and stage IV (51.1%). Subgroup analysis suggested a significantly higher proportion of the long-latent relapses originated from early primary. A series of postreirradiation complications were more frequent in patients with longer latency at reception. Conclusions. Most recurrent nasopharyngeal carcinoma is advanced disease. Patients with different recurrent interval time show different nature behavior.http://dx.doi.org/10.1100/2012/719754 |
| spellingShingle | Jia-Xin Li Tai-Xiang Lu Ying Huang Fei Han Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area The Scientific World Journal |
| title | Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area |
| title_full | Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area |
| title_fullStr | Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area |
| title_full_unstemmed | Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area |
| title_short | Clinical Characteristics of Recurrent Nasopharyngeal Carcinoma in High-Incidence Area |
| title_sort | clinical characteristics of recurrent nasopharyngeal carcinoma in high incidence area |
| url | http://dx.doi.org/10.1100/2012/719754 |
| work_keys_str_mv | AT jiaxinli clinicalcharacteristicsofrecurrentnasopharyngealcarcinomainhighincidencearea AT taixianglu clinicalcharacteristicsofrecurrentnasopharyngealcarcinomainhighincidencearea AT yinghuang clinicalcharacteristicsofrecurrentnasopharyngealcarcinomainhighincidencearea AT feihan clinicalcharacteristicsofrecurrentnasopharyngealcarcinomainhighincidencearea |