Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patients
Introduction: Viral genotype and variation in host genes involved in the immune response may predict the treatment response in patients infected with HCV. The present study was designed to determine the distribution pattern of HCV and host genotypes in Chronic Hepatitis C (CHC) patients and their a...
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The Journal of Infection in Developing Countries
2018-09-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/10175 |
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| author | Mosin S Khan Abid Shoukat Syed Mudassar Zaffar Kawoosa Altaf H Shah Showkat Ali Zargar |
| author_facet | Mosin S Khan Abid Shoukat Syed Mudassar Zaffar Kawoosa Altaf H Shah Showkat Ali Zargar |
| author_sort | Mosin S Khan |
| collection | DOAJ |
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Introduction: Viral genotype and variation in host genes involved in the immune response may predict the treatment response in patients infected with HCV. The present study was designed to determine the distribution pattern of HCV and host genotypes in Chronic Hepatitis C (CHC) patients and their association with virological response and other risk factors.
Methodology: Two hundred and fifty (n = 250) HCV positive patients were included in the study. HCV and Interleukin 28B (IL28B) genotyping was carried out by PCR-RFLP.
Results: Viral genotype 3 was the predominant genotype seen in 187 (74.8%) patients. Wild genotype predominated in rs12979860, rs12980275 and rs8099917 SNP of IL28B gene. A significant difference was found in end stage virological response (EVR) between HCV genotype 1 infected patients with wild and variant genotype for rs12980275 and rs8099917 SNPs respectively (P < 0.05). On multivariate analysis all the SNPs were found to be associated with each other (P < 0.05) with rs12980275 SNP associated with history of Jaundice (P < 0.05). Viral genotype 3 was significantly associated with age (< 50 years) and rapid virological response (RVR) while as viral genotype 1 was significantly associated with history of surgery on multivariate analysis (P < 0.05).
Conclusions: The viral genotype and IL28B polymorphisms are important factors to personalize antiviral therapy of patients with CHC.
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| format | Article |
| id | doaj-art-1a49fb9985e14c0aaa85b4e0f674300a |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-1a49fb9985e14c0aaa85b4e0f674300a2025-08-20T03:48:46ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802018-09-01120910.3855/jidc.10175Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patientsMosin S Khan0Abid Shoukat1Syed Mudassar2Zaffar Kawoosa3Altaf H Shah4Showkat Ali Zargar5Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, IndiaSher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, IndiaSher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, IndiaSher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, IndiaSher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, IndiaSher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, India Introduction: Viral genotype and variation in host genes involved in the immune response may predict the treatment response in patients infected with HCV. The present study was designed to determine the distribution pattern of HCV and host genotypes in Chronic Hepatitis C (CHC) patients and their association with virological response and other risk factors. Methodology: Two hundred and fifty (n = 250) HCV positive patients were included in the study. HCV and Interleukin 28B (IL28B) genotyping was carried out by PCR-RFLP. Results: Viral genotype 3 was the predominant genotype seen in 187 (74.8%) patients. Wild genotype predominated in rs12979860, rs12980275 and rs8099917 SNP of IL28B gene. A significant difference was found in end stage virological response (EVR) between HCV genotype 1 infected patients with wild and variant genotype for rs12980275 and rs8099917 SNPs respectively (P < 0.05). On multivariate analysis all the SNPs were found to be associated with each other (P < 0.05) with rs12980275 SNP associated with history of Jaundice (P < 0.05). Viral genotype 3 was significantly associated with age (< 50 years) and rapid virological response (RVR) while as viral genotype 1 was significantly associated with history of surgery on multivariate analysis (P < 0.05). Conclusions: The viral genotype and IL28B polymorphisms are important factors to personalize antiviral therapy of patients with CHC. https://jidc.org/index.php/journal/article/view/10175Hepatitis Cchronic hepatitis CIL28Bviral genotypePCR-RFLPhepatocellular carcinoma |
| spellingShingle | Mosin S Khan Abid Shoukat Syed Mudassar Zaffar Kawoosa Altaf H Shah Showkat Ali Zargar Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patients Journal of Infection in Developing Countries Hepatitis C chronic hepatitis C IL28B viral genotype PCR-RFLP hepatocellular carcinoma |
| title | Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patients |
| title_full | Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patients |
| title_fullStr | Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patients |
| title_full_unstemmed | Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patients |
| title_short | Impact of IL28B genetic variant's and viral genotype on treatment outcome of hepatitis C infected patients |
| title_sort | impact of il28b genetic variant s and viral genotype on treatment outcome of hepatitis c infected patients |
| topic | Hepatitis C chronic hepatitis C IL28B viral genotype PCR-RFLP hepatocellular carcinoma |
| url | https://jidc.org/index.php/journal/article/view/10175 |
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