Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach
Osteosarcoma (OS) is a lethal bone tumor that primarily affects adolescents. OS is characterized by a high incidence of recurrence following surgical intervention, which is attributed to the presence of residual microscopic disease. Tumor-associated macrophages, which dominate the tumor microenviron...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2025-05-01
|
| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25000118 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586246691487744 |
|---|---|
| author | Xiongfa Ji Xin Qian Guowen Luo Wenjie Yang Wenhan Huang Zehua Lei Jiaqi Zhou Guoqing Zhong Jielong Zhou Nan Liu Limin Ma Mei Li Xiangmei Liu Shuilin Wu Yu Zhang |
| author_facet | Xiongfa Ji Xin Qian Guowen Luo Wenjie Yang Wenhan Huang Zehua Lei Jiaqi Zhou Guoqing Zhong Jielong Zhou Nan Liu Limin Ma Mei Li Xiangmei Liu Shuilin Wu Yu Zhang |
| author_sort | Xiongfa Ji |
| collection | DOAJ |
| description | Osteosarcoma (OS) is a lethal bone tumor that primarily affects adolescents. OS is characterized by a high incidence of recurrence following surgical intervention, which is attributed to the presence of residual microscopic disease. Tumor-associated macrophages, which dominate the tumor microenvironment, often suppress immune responses and facilitate tumor progression and recurrence. This study developed an innovative nanotherapeutic approach by utilizing genetically engineered macrophage membranes with M1 polarization, stably overexpressing signal regulatory protein alpha (SIRPα), to encapsulate microwave-responsive nano-Prussian blue (SIRPα-M@nanoPB) nanoparticles. These nanoparticles induce tumor cell death selectively through hyperthermia and microwave dynamic effects upon targeted microwave irradiation. It is of critical importance to note that the enhancement of SIRPα on the nanoparticle surface actively targets and binds CD47 of tumor cells, thereby disrupting the ''don't-eat-me'' signal and effectively countering the immunosuppressive tumor environment. This action restores macrophage phagocytosis with M1 polarization, triggering potent immune responses. Our strategy holds considerable promise when it comes to improving the efficacy of microwave ablation through immune modulation, while reducing thermal damage to adjacent normal tissue and minimizing the risk of tumor recurrence. Thus, it offers a significant advancement in microwave therapies for patients with OS. |
| format | Article |
| id | doaj-art-1a3aa4540884444584b5ca7b58c77312 |
| institution | Kabale University |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-1a3aa4540884444584b5ca7b58c773122025-01-26T05:04:27ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-05-0147248265Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approachXiongfa Ji0Xin Qian1Guowen Luo2Wenjie Yang3Wenhan Huang4Zehua Lei5Jiaqi Zhou6Guoqing Zhong7Jielong Zhou8Nan Liu9Limin Ma10Mei Li11Xiangmei Liu12Shuilin Wu13Yu Zhang14Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, ChinaBeijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, No.168 Litang Road, Changping District, 100000, Beijing, ChinaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Guang Dong Engineering Technology Research Center of Functional, Repair of Bone Defects and Biomaterials, 510080, Guangzhou, China; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Guang Dong Engineering Technology Research Center of Functional, Repair of Bone Defects and Biomaterials, 510080, Guangzhou, China; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Guang Dong Engineering Technology Research Center of Functional, Repair of Bone Defects and Biomaterials, 510080, Guangzhou, China; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Guang Dong Engineering Technology Research Center of Functional, Repair of Bone Defects and Biomaterials, 510080, Guangzhou, China; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Guang Dong Engineering Technology Research Center of Functional, Repair of Bone Defects and Biomaterials, 510080, Guangzhou, China; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Guang Dong Engineering Technology Research Center of Functional, Repair of Bone Defects and Biomaterials, 510080, Guangzhou, China; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Guang Dong Engineering Technology Research Center of Functional, Repair of Bone Defects and Biomaterials, 510080, Guangzhou, China; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, ChinaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Guang Dong Engineering Technology Research Center of Functional, Repair of Bone Defects and Biomaterials, 510080, Guangzhou, China; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Corresponding author. Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China.School of Health Science & Biomedical Engineering, Hebei University of Technology, Xiping Avenue 5340, 300401, Tianjin, China; Corresponding author.School of Materials Science & Engineering, Peking University, Yi-He-Yuan Road 5, 100871, Beijing, China; Corresponding author.Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Guang Dong Engineering Technology Research Center of Functional, Repair of Bone Defects and Biomaterials, 510080, Guangzhou, China; Medical Research Center, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China; Corresponding author. Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 510080, Guangzhou, China.Osteosarcoma (OS) is a lethal bone tumor that primarily affects adolescents. OS is characterized by a high incidence of recurrence following surgical intervention, which is attributed to the presence of residual microscopic disease. Tumor-associated macrophages, which dominate the tumor microenvironment, often suppress immune responses and facilitate tumor progression and recurrence. This study developed an innovative nanotherapeutic approach by utilizing genetically engineered macrophage membranes with M1 polarization, stably overexpressing signal regulatory protein alpha (SIRPα), to encapsulate microwave-responsive nano-Prussian blue (SIRPα-M@nanoPB) nanoparticles. These nanoparticles induce tumor cell death selectively through hyperthermia and microwave dynamic effects upon targeted microwave irradiation. It is of critical importance to note that the enhancement of SIRPα on the nanoparticle surface actively targets and binds CD47 of tumor cells, thereby disrupting the ''don't-eat-me'' signal and effectively countering the immunosuppressive tumor environment. This action restores macrophage phagocytosis with M1 polarization, triggering potent immune responses. Our strategy holds considerable promise when it comes to improving the efficacy of microwave ablation through immune modulation, while reducing thermal damage to adjacent normal tissue and minimizing the risk of tumor recurrence. Thus, it offers a significant advancement in microwave therapies for patients with OS.http://www.sciencedirect.com/science/article/pii/S2452199X25000118OsteosarcomaNano prussian blueMacrophage cell membraneMicrowave responsive |
| spellingShingle | Xiongfa Ji Xin Qian Guowen Luo Wenjie Yang Wenhan Huang Zehua Lei Jiaqi Zhou Guoqing Zhong Jielong Zhou Nan Liu Limin Ma Mei Li Xiangmei Liu Shuilin Wu Yu Zhang Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach Bioactive Materials Osteosarcoma Nano prussian blue Macrophage cell membrane Microwave responsive |
| title | Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach |
| title_full | Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach |
| title_fullStr | Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach |
| title_full_unstemmed | Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach |
| title_short | Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach |
| title_sort | engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the cd47 sirpα axis a novel biomimetic immunotherapeutic approach |
| topic | Osteosarcoma Nano prussian blue Macrophage cell membrane Microwave responsive |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25000118 |
| work_keys_str_mv | AT xiongfaji engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT xinqian engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT guowenluo engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT wenjieyang engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT wenhanhuang engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT zehualei engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT jiaqizhou engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT guoqingzhong engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT jielongzhou engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT nanliu engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT liminma engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT meili engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT xiangmeiliu engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT shuilinwu engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach AT yuzhang engineeredmacrophagenanoparticlesenhancemicrowaveablationefficacyinosteosarcomaviatargetingthecd47sirpaaxisanovelbiomimeticimmunotherapeuticapproach |