Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus
Group A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases. It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is cu...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/167089 |
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| _version_ | 1832564452132651008 |
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| author | Shu Ki Tsoi Pierre R. Smeesters Hannah R. C. Frost Paul Licciardi Andrew C. Steer |
| author_facet | Shu Ki Tsoi Pierre R. Smeesters Hannah R. C. Frost Paul Licciardi Andrew C. Steer |
| author_sort | Shu Ki Tsoi |
| collection | DOAJ |
| description | Group A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases. It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is currently available. Progress in GAS vaccine development has been hindered by a number of obstacles, including a lack of standardization in immunoassays and the need to define human correlates of protection. In this review, we have examined the current immunoassays used in both GAS and other organisms, and explored the various challenges in their implementation in order to propose potential future directions to identify a correlate of protection and facilitate the development of M protein-based vaccines, which are currently the main GAS vaccine candidates. |
| format | Article |
| id | doaj-art-1a372779c7ff4484a0e4c53092432688 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-1a372779c7ff4484a0e4c530924326882025-02-03T01:10:56ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/167089167089Correlates of Protection for M Protein-Based Vaccines against Group A StreptococcusShu Ki Tsoi0Pierre R. Smeesters1Hannah R. C. Frost2Paul Licciardi3Andrew C. Steer4Group A Streptococcus Research Group, Murdoch Childrens Research Institute, Melbourne, VIC 3052, AustraliaGroup A Streptococcus Research Group, Murdoch Childrens Research Institute, Melbourne, VIC 3052, AustraliaGroup A Streptococcus Research Group, Murdoch Childrens Research Institute, Melbourne, VIC 3052, AustraliaPneumococcal Research Group, Murdoch Childrens Research Institute, Melbourne, VIC 3052, AustraliaGroup A Streptococcus Research Group, Murdoch Childrens Research Institute, Melbourne, VIC 3052, AustraliaGroup A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases. It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is currently available. Progress in GAS vaccine development has been hindered by a number of obstacles, including a lack of standardization in immunoassays and the need to define human correlates of protection. In this review, we have examined the current immunoassays used in both GAS and other organisms, and explored the various challenges in their implementation in order to propose potential future directions to identify a correlate of protection and facilitate the development of M protein-based vaccines, which are currently the main GAS vaccine candidates.http://dx.doi.org/10.1155/2015/167089 |
| spellingShingle | Shu Ki Tsoi Pierre R. Smeesters Hannah R. C. Frost Paul Licciardi Andrew C. Steer Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus Journal of Immunology Research |
| title | Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus |
| title_full | Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus |
| title_fullStr | Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus |
| title_full_unstemmed | Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus |
| title_short | Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus |
| title_sort | correlates of protection for m protein based vaccines against group a streptococcus |
| url | http://dx.doi.org/10.1155/2015/167089 |
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