Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis
Aim. To determine serum IL-1β, IL-6, IL-8, and TNF-α levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up. Methods. This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as cult...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/31397 |
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| author | A. Nese Citak Kurt A. Denizmen Aygun Ahmet Godekmerdan Abdullah Kurt Yasar Dogan Erdal Yilmaz |
| author_facet | A. Nese Citak Kurt A. Denizmen Aygun Ahmet Godekmerdan Abdullah Kurt Yasar Dogan Erdal Yilmaz |
| author_sort | A. Nese Citak Kurt |
| collection | DOAJ |
| description | Aim. To determine serum IL-1β, IL-6, IL-8, and TNF-α levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up. Methods. This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (n=12), as culture-negative sepsis (n=21), and as healthy newborns (n=17). Results. At the time of diagnosis, serum IL-1β, IL-6, IL-8, and TNF-α levels of culture-proven sepsis were significantly higher than those of the control groups (P<.05). At the time of diagnosis, IL-1β, IL-6, IL-8, and TNF-α levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment. Conclusion. Serum IL-1β, IL-6, IL-8, and TNF-α are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis. |
| format | Article |
| id | doaj-art-1a3399d21f58424cad431651856fd043 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1a3399d21f58424cad431651856fd0432025-02-03T05:48:15ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/3139731397Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal SepsisA. Nese Citak Kurt0A. Denizmen Aygun1Ahmet Godekmerdan2Abdullah Kurt3Yasar Dogan4Erdal Yilmaz5Department of Pediatrics, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Pediatrics, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Immunology, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Pediatrics, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Pediatrics, Faculty of Medicine, Firat University, Elazig 23119, TurkeyDepartment of Pediatrics, Faculty of Medicine, Firat University, Elazig 23119, TurkeyAim. To determine serum IL-1β, IL-6, IL-8, and TNF-α levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up. Methods. This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (n=12), as culture-negative sepsis (n=21), and as healthy newborns (n=17). Results. At the time of diagnosis, serum IL-1β, IL-6, IL-8, and TNF-α levels of culture-proven sepsis were significantly higher than those of the control groups (P<.05). At the time of diagnosis, IL-1β, IL-6, IL-8, and TNF-α levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment. Conclusion. Serum IL-1β, IL-6, IL-8, and TNF-α are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis.http://dx.doi.org/10.1155/2007/31397 |
| spellingShingle | A. Nese Citak Kurt A. Denizmen Aygun Ahmet Godekmerdan Abdullah Kurt Yasar Dogan Erdal Yilmaz Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis Mediators of Inflammation |
| title | Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis |
| title_full | Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis |
| title_fullStr | Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis |
| title_full_unstemmed | Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis |
| title_short | Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis |
| title_sort | serum il 1β il 6 il 8 and tnf α levels in early diagnosis and management of neonatal sepsis |
| url | http://dx.doi.org/10.1155/2007/31397 |
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