Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?
We consider a model incorporating the influence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factor-$\alpha$ can be administered to i...
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| Format: | Article |
| Language: | English |
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AIMS Press
2013-03-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.609 |
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| author | Avner Friedman Edward M. Lungu |
| author_facet | Avner Friedman Edward M. Lungu |
| author_sort | Avner Friedman |
| collection | DOAJ |
| description | We consider a model incorporating the influence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factor-$\alpha$ can be administered to inhibit malaria infection. We have also found that if the cytokine $F^*$ and a generic drug of efficacy $\epsilon$ are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low efficacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs. |
| format | Article |
| id | doaj-art-1a12d09f314e4863b30d284895bf2875 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2013-03-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-1a12d09f314e4863b30d284895bf28752025-01-24T02:26:12ZengAIMS PressMathematical Biosciences and Engineering1551-00182013-03-0110360962410.3934/mbe.2013.10.609Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha?Avner Friedman0Edward M. Lungu1MBI, Ohio State University, Columbus, OH 43210MBI, Ohio State University, Columbus, OH 43210We consider a model incorporating the influence of innate and adaptive immune responses on malaria pathogenesis. By calculating the model reproduction number for a special representation of cytokine interaction, we have shown that the cytokine tumour necrosis factor-$\alpha$ can be administered to inhibit malaria infection. We have also found that if the cytokine $F^*$ and a generic drug of efficacy $\epsilon$ are administered as dual therapy then clearance of the parasite can be achieved even for a generic drug of low efficacy. Our study is recommending administration of dual therapy as a strategy to prevent parasites from developing resistance to malaria treatment drugs.https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.609cytokines.pathogenesisadaptive immune responseinnate immune response |
| spellingShingle | Avner Friedman Edward M. Lungu Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha? Mathematical Biosciences and Engineering cytokines. pathogenesis adaptive immune response innate immune response |
| title | Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha? |
| title_full | Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha? |
| title_fullStr | Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha? |
| title_full_unstemmed | Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha? |
| title_short | Can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor-alpha? |
| title_sort | can malaria parasite pathogenesis be prevented by treatment with tumor necrosis factor alpha |
| topic | cytokines. pathogenesis adaptive immune response innate immune response |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.609 |
| work_keys_str_mv | AT avnerfriedman canmalariaparasitepathogenesisbepreventedbytreatmentwithtumornecrosisfactoralpha AT edwardmlungu canmalariaparasitepathogenesisbepreventedbytreatmentwithtumornecrosisfactoralpha |