The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALD
Background: The liver disorders caused by alcohol abuse are termed alcoholic-related liver disease (ALD), including alcoholic steatosis, alcoholic steatohepatitis, alcoholic hepatitis, and alcoholic cirrhosis, posing a significant threat to human health. Currently, ALD pathogenesis has not been comp...
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Elsevier
2025-06-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123224002686 |
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| author | Zilu Cheng Ling Yang Huikuan Chu |
| author_facet | Zilu Cheng Ling Yang Huikuan Chu |
| author_sort | Zilu Cheng |
| collection | DOAJ |
| description | Background: The liver disorders caused by alcohol abuse are termed alcoholic-related liver disease (ALD), including alcoholic steatosis, alcoholic steatohepatitis, alcoholic hepatitis, and alcoholic cirrhosis, posing a significant threat to human health. Currently, ALD pathogenesis has not been completely clarified, which is likely to be related to the direct damage caused by alcohol and its metabolic products, oxidative stress, gut dysbiosis, and exosomes. Aims: The existing studies suggest that both the gut microbiota and exosomes contribute to the development of ALD. Moreover, there exists an interaction between the gut microbiota and exosomes. We discuss whether this interaction plays a role in the pathogenesis of ALD and whether it can be a potential therapeutic target for ALD treatment. Key scientific concepts of review: Chronic alcohol intake alters the diversity and composition of gut microbiota, which greatly contributes to ALD’s progression. Some approaches targeting the gut microbiota, including probiotics, fecal microbiota transplantation, and phage therapy, have been confirmed to effectively ameliorate ALD in many animal experiments and/or several clinical trials. In ALD, the levels of exosomes and the expression profile of microRNA have also changed, which affects the pathogenesis of ALD. Moreover, there is an interplay between exosomes and the gut microbiota, which also putatively acts as a pathogenic factor of ALD. |
| format | Article |
| id | doaj-art-1a0c9837ee6e4617a2a7c7bbf6a2c68d |
| institution | DOAJ |
| issn | 2090-1232 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
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| series | Journal of Advanced Research |
| spelling | doaj-art-1a0c9837ee6e4617a2a7c7bbf6a2c68d2025-08-20T03:08:20ZengElsevierJournal of Advanced Research2090-12322025-06-017235336710.1016/j.jare.2024.07.002The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALDZilu Cheng0Ling Yang1Huikuan Chu2Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, ChinaCorresponding authors at: Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, ChinaCorresponding authors at: Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China.; Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan, Hubei Province 430022, ChinaBackground: The liver disorders caused by alcohol abuse are termed alcoholic-related liver disease (ALD), including alcoholic steatosis, alcoholic steatohepatitis, alcoholic hepatitis, and alcoholic cirrhosis, posing a significant threat to human health. Currently, ALD pathogenesis has not been completely clarified, which is likely to be related to the direct damage caused by alcohol and its metabolic products, oxidative stress, gut dysbiosis, and exosomes. Aims: The existing studies suggest that both the gut microbiota and exosomes contribute to the development of ALD. Moreover, there exists an interaction between the gut microbiota and exosomes. We discuss whether this interaction plays a role in the pathogenesis of ALD and whether it can be a potential therapeutic target for ALD treatment. Key scientific concepts of review: Chronic alcohol intake alters the diversity and composition of gut microbiota, which greatly contributes to ALD’s progression. Some approaches targeting the gut microbiota, including probiotics, fecal microbiota transplantation, and phage therapy, have been confirmed to effectively ameliorate ALD in many animal experiments and/or several clinical trials. In ALD, the levels of exosomes and the expression profile of microRNA have also changed, which affects the pathogenesis of ALD. Moreover, there is an interplay between exosomes and the gut microbiota, which also putatively acts as a pathogenic factor of ALD.http://www.sciencedirect.com/science/article/pii/S2090123224002686Alcoholic-related liver diseaseGut microbiotaExosomes |
| spellingShingle | Zilu Cheng Ling Yang Huikuan Chu The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALD Journal of Advanced Research Alcoholic-related liver disease Gut microbiota Exosomes |
| title | The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALD |
| title_full | The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALD |
| title_fullStr | The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALD |
| title_full_unstemmed | The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALD |
| title_short | The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALD |
| title_sort | role of gut microbiota exosomes and their interaction in the pathogenesis of ald |
| topic | Alcoholic-related liver disease Gut microbiota Exosomes |
| url | http://www.sciencedirect.com/science/article/pii/S2090123224002686 |
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