New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function
Recent advances in immunology have challenged the conventional division of T-lymphocyte function by uncovering novel subpopulations with diverse roles and characteristics. This article reviews these discoveries and their implications for understanding immune regulation and disease pathogenesis. Inno...
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2024-11-01
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| Series: | Central European Journal of Immunology |
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| Online Access: | https://www.termedia.pl/New-T-lymphocyte-subpopulations-and-their-characteristics-Challenges-to-the-classical-division-of-lymphocyte-function,10,54976,1,1.html |
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| _version_ | 1832584772012998656 |
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| author | Filip Lewandowski Paulina Niedźwiedzka-Rystwej |
| author_facet | Filip Lewandowski Paulina Niedźwiedzka-Rystwej |
| author_sort | Filip Lewandowski |
| collection | DOAJ |
| description | Recent advances in immunology have challenged the conventional division of T-lymphocyte function by uncovering novel subpopulations with diverse roles and characteristics. This article reviews these discoveries and their implications for understanding immune regulation and disease pathogenesis. Innovative techniques have enabled the identification of previously unrecognized T-lymphocyte subsets, disrupting the classical classification system. Helper lymphocytes, including T fh1 , T fh2 , T fh17 , GC-T fh , and circulating T fh cells, exhibit distinct functions in immune responses and disease states. Additionally, newly identified cytotoxic T-cell subsets, such as CD8 + CD39 + and CD8 + CD28 + cells, demonstrate unique effector properties with potential therapeutic applications in cancer immunotherapy. Furthermore, the discovery of CD20 + T cells challenges traditional views, offering new avenues for immunotherapy in cancer, autoimmune disorders, and infectious diseases. These findings expand our understanding of T-lymphocyte biology and suggest targets for more effective therapeutic interventions. Further research is essential to fully elucidate the clinical relevance and therapeutic potential of these T-lymphocyte subpopulations, paving the way for personalized and targeted immune-based treatments. |
| format | Article |
| id | doaj-art-1a0805b6b8164a31b9ab2b9ffd5aef64 |
| institution | Kabale University |
| issn | 1426-3912 1644-4124 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Central European Journal of Immunology |
| spelling | doaj-art-1a0805b6b8164a31b9ab2b9ffd5aef642025-01-27T11:13:18ZengTermedia Publishing HouseCentral European Journal of Immunology1426-39121644-41242024-11-0149330831410.5114/ceji.2024.14407154976New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte functionFilip LewandowskiPaulina Niedźwiedzka-RystwejRecent advances in immunology have challenged the conventional division of T-lymphocyte function by uncovering novel subpopulations with diverse roles and characteristics. This article reviews these discoveries and their implications for understanding immune regulation and disease pathogenesis. Innovative techniques have enabled the identification of previously unrecognized T-lymphocyte subsets, disrupting the classical classification system. Helper lymphocytes, including T fh1 , T fh2 , T fh17 , GC-T fh , and circulating T fh cells, exhibit distinct functions in immune responses and disease states. Additionally, newly identified cytotoxic T-cell subsets, such as CD8 + CD39 + and CD8 + CD28 + cells, demonstrate unique effector properties with potential therapeutic applications in cancer immunotherapy. Furthermore, the discovery of CD20 + T cells challenges traditional views, offering new avenues for immunotherapy in cancer, autoimmune disorders, and infectious diseases. These findings expand our understanding of T-lymphocyte biology and suggest targets for more effective therapeutic interventions. Further research is essential to fully elucidate the clinical relevance and therapeutic potential of these T-lymphocyte subpopulations, paving the way for personalized and targeted immune-based treatments.https://www.termedia.pl/New-T-lymphocyte-subpopulations-and-their-characteristics-Challenges-to-the-classical-division-of-lymphocyte-function,10,54976,1,1.htmlt cells lymphocytes division lymphocyte subpopulation follicular lymphocytes cytotoxic lymphocytes regulatory lymphocytes cd20<sup>+</sup> lymphocytes |
| spellingShingle | Filip Lewandowski Paulina Niedźwiedzka-Rystwej New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function Central European Journal of Immunology t cells lymphocytes division lymphocyte subpopulation follicular lymphocytes cytotoxic lymphocytes regulatory lymphocytes cd20<sup>+</sup> lymphocytes |
| title | New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function |
| title_full | New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function |
| title_fullStr | New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function |
| title_full_unstemmed | New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function |
| title_short | New T-lymphocyte subpopulations and their characteristics: Challenges to the classical division of lymphocyte function |
| title_sort | new t lymphocyte subpopulations and their characteristics challenges to the classical division of lymphocyte function |
| topic | t cells lymphocytes division lymphocyte subpopulation follicular lymphocytes cytotoxic lymphocytes regulatory lymphocytes cd20<sup>+</sup> lymphocytes |
| url | https://www.termedia.pl/New-T-lymphocyte-subpopulations-and-their-characteristics-Challenges-to-the-classical-division-of-lymphocyte-function,10,54976,1,1.html |
| work_keys_str_mv | AT filiplewandowski newtlymphocytesubpopulationsandtheircharacteristicschallengestotheclassicaldivisionoflymphocytefunction AT paulinaniedzwiedzkarystwej newtlymphocytesubpopulationsandtheircharacteristicschallengestotheclassicaldivisionoflymphocytefunction |