Neurodevelopmental defects in Dravet syndrome Scn1a+/− mice: Targeting GABA-switch rescues behavioral dysfunctions but not seizures and mortality

Neurodevelopmental defects in Dravet syndrome Scn1a+/− mice: Targeting GABA-switch rescues behavioral dysfunctions but not seizures and mortality

Dravet syndrome (DS) is a developmental and epileptic encephalopathy (DEE) caused by mutations of the SCN1A gene (NaV1.1 sodium channel) and characterized by seizures, motor disabilities and cognitive/behavioral deficits, including autistic traits. The relative role of seizures and neurodevelopmenta...

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Bibliographic Details
Main Authors: Lara Pizzamiglio, Fabrizio Capitano, Evgeniia Rusina, Giuliana Fossati, Elisabetta Menna, Isabelle Léna, Flavia Antonucci, Massimo Mantegazza
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Neurobiology of Disease
Subjects:
Developmental and epileptic encephalopathy
GABA
Epilepsy
Autism
Nav1.1
Sodium channel
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000695
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