A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia
Importance. As Rivaroxaban has increased in popularity, it has been accompanied with a growing body of evidence displaying its ability to cause drug induced liver injury (DILI). Observation. A 74-year-old Caucasian female developed Rivaroxaban DILI two weeks after finishing a 14-day course. The pati...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/5678187 |
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| author | Keith Glenn Patrick Chen Mustafa Musleh Rao Pallivi Melissa Grilliot |
| author_facet | Keith Glenn Patrick Chen Mustafa Musleh Rao Pallivi Melissa Grilliot |
| author_sort | Keith Glenn |
| collection | DOAJ |
| description | Importance. As Rivaroxaban has increased in popularity, it has been accompanied with a growing body of evidence displaying its ability to cause drug induced liver injury (DILI). Observation. A 74-year-old Caucasian female developed Rivaroxaban DILI two weeks after finishing a 14-day course. The patient was symptomatic and jaundiced with elevated transaminases and hyperbilirubinemia with normal lab values two months priorly. Liver biopsies showed mixed inflammatory infiltrate of lymphocytes, neutrophils and eosinophils, rare necrotic hepatocytes, and canalicular and intrahepatocellular cholestasis, all of which are consistent with DILI. Conclusion and Relevance. We present this case to add to the growing evidence that Rivaroxaban can be associated with severe, symptomatic liver injury and to ensure physicians are aware of these possible side effects of novel anticoagulants with their increasing use. |
| format | Article |
| id | doaj-art-19f818cd3ec64cc1a2938df650e8d5ef |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-19f818cd3ec64cc1a2938df650e8d5ef2025-02-03T05:48:16ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362017-01-01201710.1155/2017/56781875678187A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and HyperbilirubinemiaKeith Glenn0Patrick Chen1Mustafa Musleh2Rao Pallivi3Melissa Grilliot4Department of Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH, USADepartment of Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH, USADepartment of Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH, USADepartment of Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH, USADepartment of Internal Medicine, Wright State University Boonshoft School of Medicine, Dayton, OH, USAImportance. As Rivaroxaban has increased in popularity, it has been accompanied with a growing body of evidence displaying its ability to cause drug induced liver injury (DILI). Observation. A 74-year-old Caucasian female developed Rivaroxaban DILI two weeks after finishing a 14-day course. The patient was symptomatic and jaundiced with elevated transaminases and hyperbilirubinemia with normal lab values two months priorly. Liver biopsies showed mixed inflammatory infiltrate of lymphocytes, neutrophils and eosinophils, rare necrotic hepatocytes, and canalicular and intrahepatocellular cholestasis, all of which are consistent with DILI. Conclusion and Relevance. We present this case to add to the growing evidence that Rivaroxaban can be associated with severe, symptomatic liver injury and to ensure physicians are aware of these possible side effects of novel anticoagulants with their increasing use.http://dx.doi.org/10.1155/2017/5678187 |
| spellingShingle | Keith Glenn Patrick Chen Mustafa Musleh Rao Pallivi Melissa Grilliot A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia Case Reports in Gastrointestinal Medicine |
| title | A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia |
| title_full | A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia |
| title_fullStr | A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia |
| title_full_unstemmed | A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia |
| title_short | A Rare Case of Rivaroxaban Causing Delayed Symptomatic Hepatocellular Injury and Hyperbilirubinemia |
| title_sort | rare case of rivaroxaban causing delayed symptomatic hepatocellular injury and hyperbilirubinemia |
| url | http://dx.doi.org/10.1155/2017/5678187 |
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