Association between cardiovascular health and osteoporotic fractures: a national population-based study
Abstract Osteoporotic fractures are a major public health concern, particularly among the aging population, as they significantly contribute to morbidity, mortality, and reduced quality of life. While cardiovascular health (CVH) has traditionally been linked to cardiovascular disease outcomes, emerg...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88020-5 |
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| author | Jun Ou Tingting Wang Ridan Lei Mengting Sun Xiaorui Ruan Jianhui Wei Jiabi Qin |
| author_facet | Jun Ou Tingting Wang Ridan Lei Mengting Sun Xiaorui Ruan Jianhui Wei Jiabi Qin |
| author_sort | Jun Ou |
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| description | Abstract Osteoporotic fractures are a major public health concern, particularly among the aging population, as they significantly contribute to morbidity, mortality, and reduced quality of life. While cardiovascular health (CVH) has traditionally been linked to cardiovascular disease outcomes, emerging evidence suggests it may also influence bone health. This study investigates the association between CVH, as measured by the Life’s Essential 8 (LE8) score, and the prevalence of osteoporotic fractures in U.S. adults. This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. A total of 17,606 adults aged 20 and above were included in the analysis after excluding participants with missing data on CVH or osteoporotic fractures. CVH was assessed using the LE8 score, which incorporates eight modifiable cardiovascular health metrics: diet, physical activity, tobacco use, sleep, body mass index (BMI), lipid levels, blood glucose, and blood pressure. The primary outcome, osteoporotic fractures, was identified through self-reported data confirmed by a physician. Weighted multivariate logistic regression models were used to estimate the association between CVH and the prevalence of osteoporotic fractures, adjusting for demographic and health-related covariates. Participants with higher CVH scores had a lower prevalence of osteoporotic fractures. In the fully adjusted model, each 1-point increase in the LE8 score was associated with a 1% reduction in the odds of osteoporotic fractures (OR = 0.99, 95% CI: 0.98–0.99). Compared to participants with low CVH levels, those with moderate CVH had a 22% lower odds of osteoporotic fractures (OR = 0.78, 95% CI 0.70–0.87), and those with high CVH had a 34% lower odds (OR = 0.66, 95% CI 0.56–0.79). A significant linear trend was observed across different CVH levels (P for trend < 0.001). Subgroup analyses revealed that the inverse relationship between CVH and osteoporotic fractures was consistent across different demographic and health-related subgroups. This study highlights a significant inverse association between cardiovascular health and osteoporotic fractures in U.S. adults. These findings suggest that maintaining a high level of cardiovascular health, as measured by the LE8 score, may be important in reducing the risk of osteoporotic fractures. Public health strategies that integrate cardiovascular and bone health interventions may enhance overall health outcomes and reduce the societal burden of both cardiovascular diseases and osteoporosis. |
| format | Article |
| id | doaj-art-19f5e95b2dac4bcdbf6d23ce5efab95e |
| institution | Kabale University |
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| spelling | doaj-art-19f5e95b2dac4bcdbf6d23ce5efab95e2025-02-02T12:23:44ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-88020-5Association between cardiovascular health and osteoporotic fractures: a national population-based studyJun Ou0Tingting Wang1Ridan Lei2Mengting Sun3Xiaorui Ruan4Jianhui Wei5Jiabi Qin6Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityDepartment of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South UniversityAbstract Osteoporotic fractures are a major public health concern, particularly among the aging population, as they significantly contribute to morbidity, mortality, and reduced quality of life. While cardiovascular health (CVH) has traditionally been linked to cardiovascular disease outcomes, emerging evidence suggests it may also influence bone health. This study investigates the association between CVH, as measured by the Life’s Essential 8 (LE8) score, and the prevalence of osteoporotic fractures in U.S. adults. This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. A total of 17,606 adults aged 20 and above were included in the analysis after excluding participants with missing data on CVH or osteoporotic fractures. CVH was assessed using the LE8 score, which incorporates eight modifiable cardiovascular health metrics: diet, physical activity, tobacco use, sleep, body mass index (BMI), lipid levels, blood glucose, and blood pressure. The primary outcome, osteoporotic fractures, was identified through self-reported data confirmed by a physician. Weighted multivariate logistic regression models were used to estimate the association between CVH and the prevalence of osteoporotic fractures, adjusting for demographic and health-related covariates. Participants with higher CVH scores had a lower prevalence of osteoporotic fractures. In the fully adjusted model, each 1-point increase in the LE8 score was associated with a 1% reduction in the odds of osteoporotic fractures (OR = 0.99, 95% CI: 0.98–0.99). Compared to participants with low CVH levels, those with moderate CVH had a 22% lower odds of osteoporotic fractures (OR = 0.78, 95% CI 0.70–0.87), and those with high CVH had a 34% lower odds (OR = 0.66, 95% CI 0.56–0.79). A significant linear trend was observed across different CVH levels (P for trend < 0.001). Subgroup analyses revealed that the inverse relationship between CVH and osteoporotic fractures was consistent across different demographic and health-related subgroups. This study highlights a significant inverse association between cardiovascular health and osteoporotic fractures in U.S. adults. These findings suggest that maintaining a high level of cardiovascular health, as measured by the LE8 score, may be important in reducing the risk of osteoporotic fractures. Public health strategies that integrate cardiovascular and bone health interventions may enhance overall health outcomes and reduce the societal burden of both cardiovascular diseases and osteoporosis.https://doi.org/10.1038/s41598-025-88020-5CVHLE8Osteoporotic fracturesOsteoporosisNHANES |
| spellingShingle | Jun Ou Tingting Wang Ridan Lei Mengting Sun Xiaorui Ruan Jianhui Wei Jiabi Qin Association between cardiovascular health and osteoporotic fractures: a national population-based study Scientific Reports CVH LE8 Osteoporotic fractures Osteoporosis NHANES |
| title | Association between cardiovascular health and osteoporotic fractures: a national population-based study |
| title_full | Association between cardiovascular health and osteoporotic fractures: a national population-based study |
| title_fullStr | Association between cardiovascular health and osteoporotic fractures: a national population-based study |
| title_full_unstemmed | Association between cardiovascular health and osteoporotic fractures: a national population-based study |
| title_short | Association between cardiovascular health and osteoporotic fractures: a national population-based study |
| title_sort | association between cardiovascular health and osteoporotic fractures a national population based study |
| topic | CVH LE8 Osteoporotic fractures Osteoporosis NHANES |
| url | https://doi.org/10.1038/s41598-025-88020-5 |
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