LRP1-mediated p-tau propagation contributes to cognitive impairment after chronic neuropathic pain in rats

Trigeminal neuralgia (TN) is a prevalent chronic neuropathic pain syndrome characterized by severe pain, often accompanied by cognitive dysfunction and cerebral degeneration. However, its mechanisms remain poorly understood. Hyperphosphorylation of tau protein (p-tau) is often seen in neurodegenerat...

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Bibliographic Details
Main Authors: Youzhi Ning, Yue Zhang, Tao Jiang, Jianguo Feng, Jian Zhan, Cehua Ou, Lu Wang
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neuroscience Research
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Online Access:http://www.sciencedirect.com/science/article/pii/S016801022400155X
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