Clinical Features and Outcome of Mucormycosis
Mucormycosis (MCM) is a life-threatening infection that carries high mortality rates despite recent advances in its diagnosis and treatment. The objective was to report 14 cases of mucormycosis infection and review the relevant literature. We retrospectively analyzed the demographic and clinical dat...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2014/562610 |
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| author | Carlos Rodrigo Camara-Lemarroy Emmanuel Irineo González-Moreno René Rodríguez-Gutiérrez Erick Joel Rendón-Ramírez Ana Sofía Ayala-Cortés Martha Lizeth Fraga-Hernández Laura García-Labastida Dionicio Ángel Galarza-Delgado |
| author_facet | Carlos Rodrigo Camara-Lemarroy Emmanuel Irineo González-Moreno René Rodríguez-Gutiérrez Erick Joel Rendón-Ramírez Ana Sofía Ayala-Cortés Martha Lizeth Fraga-Hernández Laura García-Labastida Dionicio Ángel Galarza-Delgado |
| author_sort | Carlos Rodrigo Camara-Lemarroy |
| collection | DOAJ |
| description | Mucormycosis (MCM) is a life-threatening infection that carries high mortality rates despite recent advances in its diagnosis and treatment. The objective was to report 14 cases of mucormycosis infection and review the relevant literature. We retrospectively analyzed the demographic and clinical data of 14 consecutive patients that presented with MCM in a tertiary-care teaching hospital in northern Mexico. The mean age of the patients was 39.9 (range 5–65). Nine of the patients were male. Ten patients had diabetes mellitus as the underlying disease, and 6 patients had a hematological malignancy (acute leukemia). Of the diabetic patients, 3 had chronic renal failure and 4 presented with diabetic ketoacidosis. All patients had rhinocerebral involvement. In-hospital mortality was 50%. All patients received medical therapy with polyene antifungals and 11 patients underwent surgical therapy. Survivors were significantly younger and less likely to have diabetes than nonsurvivors, and had higher levels of serum albumin on admission. The clinical outcome of patients with MCM is poor. Uncontrolled diabetes and age are negative prognostic factors. |
| format | Article |
| id | doaj-art-19f1048d2e7148088de281274dfd6ff6 |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-19f1048d2e7148088de281274dfd6ff62025-02-03T00:59:49ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982014-01-01201410.1155/2014/562610562610Clinical Features and Outcome of MucormycosisCarlos Rodrigo Camara-Lemarroy0Emmanuel Irineo González-Moreno1René Rodríguez-Gutiérrez2Erick Joel Rendón-Ramírez3Ana Sofía Ayala-Cortés4Martha Lizeth Fraga-Hernández5Laura García-Labastida6Dionicio Ángel Galarza-Delgado7Departamento de Medicina Interna, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, MexicoDepartamento de Medicina Interna, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, MexicoDepartamento de Medicina Interna, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, MexicoDepartamento de Medicina Interna, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, MexicoDepartamento de Medicina Interna, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, MexicoServicio de Anatomia Patologica, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, MexicoServicio de Anatomia Patologica, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, MexicoDepartamento de Medicina Interna, Hospital Universitario “Dr. José E. González”, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, 64460 Monterrey, NL, MexicoMucormycosis (MCM) is a life-threatening infection that carries high mortality rates despite recent advances in its diagnosis and treatment. The objective was to report 14 cases of mucormycosis infection and review the relevant literature. We retrospectively analyzed the demographic and clinical data of 14 consecutive patients that presented with MCM in a tertiary-care teaching hospital in northern Mexico. The mean age of the patients was 39.9 (range 5–65). Nine of the patients were male. Ten patients had diabetes mellitus as the underlying disease, and 6 patients had a hematological malignancy (acute leukemia). Of the diabetic patients, 3 had chronic renal failure and 4 presented with diabetic ketoacidosis. All patients had rhinocerebral involvement. In-hospital mortality was 50%. All patients received medical therapy with polyene antifungals and 11 patients underwent surgical therapy. Survivors were significantly younger and less likely to have diabetes than nonsurvivors, and had higher levels of serum albumin on admission. The clinical outcome of patients with MCM is poor. Uncontrolled diabetes and age are negative prognostic factors.http://dx.doi.org/10.1155/2014/562610 |
| spellingShingle | Carlos Rodrigo Camara-Lemarroy Emmanuel Irineo González-Moreno René Rodríguez-Gutiérrez Erick Joel Rendón-Ramírez Ana Sofía Ayala-Cortés Martha Lizeth Fraga-Hernández Laura García-Labastida Dionicio Ángel Galarza-Delgado Clinical Features and Outcome of Mucormycosis Interdisciplinary Perspectives on Infectious Diseases |
| title | Clinical Features and Outcome of Mucormycosis |
| title_full | Clinical Features and Outcome of Mucormycosis |
| title_fullStr | Clinical Features and Outcome of Mucormycosis |
| title_full_unstemmed | Clinical Features and Outcome of Mucormycosis |
| title_short | Clinical Features and Outcome of Mucormycosis |
| title_sort | clinical features and outcome of mucormycosis |
| url | http://dx.doi.org/10.1155/2014/562610 |
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