Association between COVID-19 severity and relatively high serum adiponectin levels at the time of admission
At the beginning of 2020, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to epidemics worldwide. Obesity and visceral fat accumulation have been reported to be independent risk factors for severe COVID-19. Several reports have focused o...
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| Format: | Article |
| Language: | English |
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The Japan Endocrine Society
2024-07-01
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| Series: | Endocrine Journal |
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| Online Access: | https://www.jstage.jst.go.jp/article/endocrj/71/7/71_EJ24-0072/_html/-char/en |
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| author | Ryohei Mineo Shiro Fukuda Shigehito Suzuki Yoshito Ito Sachiko Tamba Takuya Sugiyama Yuya Fujishima Hitoshi Nishizawa Iichiro Shimomura Koji Yamamoto Yuji Matsuzawa |
| author_facet | Ryohei Mineo Shiro Fukuda Shigehito Suzuki Yoshito Ito Sachiko Tamba Takuya Sugiyama Yuya Fujishima Hitoshi Nishizawa Iichiro Shimomura Koji Yamamoto Yuji Matsuzawa |
| author_sort | Ryohei Mineo |
| collection | DOAJ |
| description | At the beginning of 2020, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to epidemics worldwide. Obesity and visceral fat accumulation have been reported to be independent risk factors for severe COVID-19. Several reports have focused on the levels of adipocytokines/adipokines, including adiponectin (APN), which is exclusively secreted from adipocytes, although the importance of these factors in acute disease conditions remains unclear. Therefore, we investigated the relationship between serum adiponectin levels and COVID-19 severity. Patients with COVID-19 who were admitted to Sumitomo Hospital (Osaka, Japan) from May through October 2021 were included. A total of 107 patients were enrolled in this study. We obtained the anthropometric and clinical laboratory data of the patients at the time of admission and examined the associations between various parameters and COVID-19 severity. The mean period from onset to admission was 6.5 ± 2.8 days. We divided the patients into “non-severe” (mild, moderate-I and moderate-II) (n = 80) and “severe” (n = 27) groups. The “severe” patients were significantly older than “non-severe” patients. Additionally, no significant differences were observed in BMI, sex, or the period from onset to admission. The serum adiponectin levels of “severe” patients at the time of admission were significantly greater than those of “non-severe” patients even after adjusting for age, sex, and BMI. These results suggest that the serum APN levels at the time of admission can predict COVID-19 severity. However, further investigations on the changes in APN levels in acute diseases are needed. |
| format | Article |
| id | doaj-art-19dcc408f73c4238b091b180ca2abbaa |
| institution | Kabale University |
| issn | 1348-4540 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | The Japan Endocrine Society |
| record_format | Article |
| series | Endocrine Journal |
| spelling | doaj-art-19dcc408f73c4238b091b180ca2abbaa2025-01-22T05:12:18ZengThe Japan Endocrine SocietyEndocrine Journal1348-45402024-07-0171770571110.1507/endocrj.EJ24-0072endocrjAssociation between COVID-19 severity and relatively high serum adiponectin levels at the time of admissionRyohei Mineo0Shiro Fukuda1Shigehito Suzuki2Yoshito Ito3Sachiko Tamba4Takuya Sugiyama5Yuya Fujishima6Hitoshi Nishizawa7Iichiro Shimomura8Koji Yamamoto9Yuji Matsuzawa10Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Endocrinology and Metabolism, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Endocrinology and Metabolism, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Endocrinology and Metabolism, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Endocrinology and Metabolism, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, JapanDepartment of Endocrinology and Metabolism, Sumitomo Hospital, Osaka 530-0005, JapanDepartment of Endocrinology and Metabolism, Sumitomo Hospital, Osaka 530-0005, JapanAt the beginning of 2020, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to epidemics worldwide. Obesity and visceral fat accumulation have been reported to be independent risk factors for severe COVID-19. Several reports have focused on the levels of adipocytokines/adipokines, including adiponectin (APN), which is exclusively secreted from adipocytes, although the importance of these factors in acute disease conditions remains unclear. Therefore, we investigated the relationship between serum adiponectin levels and COVID-19 severity. Patients with COVID-19 who were admitted to Sumitomo Hospital (Osaka, Japan) from May through October 2021 were included. A total of 107 patients were enrolled in this study. We obtained the anthropometric and clinical laboratory data of the patients at the time of admission and examined the associations between various parameters and COVID-19 severity. The mean period from onset to admission was 6.5 ± 2.8 days. We divided the patients into “non-severe” (mild, moderate-I and moderate-II) (n = 80) and “severe” (n = 27) groups. The “severe” patients were significantly older than “non-severe” patients. Additionally, no significant differences were observed in BMI, sex, or the period from onset to admission. The serum adiponectin levels of “severe” patients at the time of admission were significantly greater than those of “non-severe” patients even after adjusting for age, sex, and BMI. These results suggest that the serum APN levels at the time of admission can predict COVID-19 severity. However, further investigations on the changes in APN levels in acute diseases are needed.https://www.jstage.jst.go.jp/article/endocrj/71/7/71_EJ24-0072/_html/-char/enadiponectincovid-19sars-cov-2severityacute phase of disease |
| spellingShingle | Ryohei Mineo Shiro Fukuda Shigehito Suzuki Yoshito Ito Sachiko Tamba Takuya Sugiyama Yuya Fujishima Hitoshi Nishizawa Iichiro Shimomura Koji Yamamoto Yuji Matsuzawa Association between COVID-19 severity and relatively high serum adiponectin levels at the time of admission Endocrine Journal adiponectin covid-19 sars-cov-2 severity acute phase of disease |
| title | Association between COVID-19 severity and relatively high serum adiponectin levels at the time of admission |
| title_full | Association between COVID-19 severity and relatively high serum adiponectin levels at the time of admission |
| title_fullStr | Association between COVID-19 severity and relatively high serum adiponectin levels at the time of admission |
| title_full_unstemmed | Association between COVID-19 severity and relatively high serum adiponectin levels at the time of admission |
| title_short | Association between COVID-19 severity and relatively high serum adiponectin levels at the time of admission |
| title_sort | association between covid 19 severity and relatively high serum adiponectin levels at the time of admission |
| topic | adiponectin covid-19 sars-cov-2 severity acute phase of disease |
| url | https://www.jstage.jst.go.jp/article/endocrj/71/7/71_EJ24-0072/_html/-char/en |
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