Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial Agents

Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial Agents

A new series of 1,3-pyrimidine derivatives (3a-f) have been synthesized by reacting 2,4,6-Trichloropyrimidine with nucleophilic reagents 2-amino-6-fluorobenzothiazole (1) in the presence of acetone. The (4,6- dichloro-pyrimidin-2-yl)-amine (2) so produced was then reacted to two moles of phenylthi...

Full description

Saved in:

Bibliographic Details
Main Authors:	Anoop K. Pathak, Viney Chawla, Shailendra K. Saraf
Format:	Article
Language:	English
Published:	Wiley 2011-01-01
Series:	E-Journal of Chemistry
Online Access:	http://dx.doi.org/10.1155/2011/820718
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives
by: Anamika Sharma, et al.
Published: (2017-01-01)

4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies
by: Ashanul Haque, et al.
Published: (2025-01-01)

Thermodynamic Studies of [M+2] Complexes with 3-Hydroxy-2-(3-(4-Nitrobenzoyl) Thiouriedo) Propanoic Acid
by: Basima M. Sarhan, et al.
Published: (2025-01-01)

The Intermediate State: Revelation 6:9–11 and 20:4–6, 13 in the Light of Daniel 12:2, 13
by: Bohdan Kuryliak, et al.
Published: (2025-01-01)

Separation of Functionalized 5,6-Disubstituted-1,10-Phenanthroline for Dye-Sensitized Solar Cell Applications
by: Hashem Shahroosvand, et al.
Published: (2013-01-01)

Synthesis of 2-[4-(10H-Substituted Phenothiazine-3-yl)-6-Pyrimidin-2-Phenylthiol/ol/amine/thiol] Pyrroles
by: Meghasham Narule, et al.
Published: (2007-01-01)

Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones
by: A. K. Parekh, et al.
Published: (2005-01-01)

Studies on Synthesis of Some Novel Heterocyclic Chalcone, Pyrazoline, Pyrimidine - 2 - One, Pyrimidine - 2 - Thione, para-Acetanilide Sulphonyl and Benzoyl Derivatives and their Antimicrobial Activity
by: Rakesh N. Mistry, et al.
Published: (2005-01-01)

Synthesis and In Vitro Antimicrobial, Anthelmintic and Insecticidal Activities Study of 4(4'-Bromophenyl)-6-substituted-aryl-1-acetyl pyrimidine-2-thiols
by: Rita Bamnela, et al.
Published: (2010-01-01)

The crystal structure of diaqua-bis(pyrazolo[1,5-a]pyrimidine-3-carboxylato-κ2N,O)manganese(II), C14H12N6O6Mn
by: Hong Dong-Feng, et al.
Published: (2022-08-01)

Thioxopyrimidine in Heterocyclic Synthesis I: Synthesis of Some Novel 6-(Heteroatom-substituted)-(thio)pyrimidine Derivatives
by: Yuh-Wen Ho, et al.
Published: (2013-01-01)

GJB6-D13S1830 and GJB6-D13S1854 Deletions in Patients with non-Syndromic Prelingual Deafness
by: Mercedes Arceo Álvarez, et al.
Published: (2024-08-01)

Synthesis and Biological Activity of Some 3,4-Dihydro-4-(4-substituted aryl)-6-(naptho[2,1-b]furan-2-yl pyrimidine-2(1H)-one Derivatives
by: Sanjeevan S. Gaikwad, et al.
Published: (2012-01-01)

Crystal structure of 6-(pyridin-3-yl)-1,3,5-triazine-2,4-diamine-sebacic acid (2/1), C13H17N6O2
by: Wang Zhi-Yong, et al.
Published: (2023-10-01)

Synthesis, Characterization and Biological Evaluation of 1, 2-Disubstituted Benzimidazole Derivatives using Mannich Bases
by: B. Anil Reddy
Published: (2010-01-01)

Crystal structure of (1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)(4-((2-methyl-6-(trifluoromethyl)pyrimidin-4-yl)amino)piperidin-1-yl)methanone, C17H18F6N6O
by: Pan Nian-Juan, et al.
Published: (2023-10-01)

Ultrasonic Irradiation: Synthesis, Characterization, and Preliminary Antimicrobial Activity of Novel Series of 4,6-Disubstituted-1,3,5-triazine Containing Hydrazone Derivatives
by: Hessa H. Al-Rasheed, et al.
Published: (2016-01-01)

The crystal structure of 4-((6-fluoropyridin-2-yloxy)methyl)benzonitrile, C13H9FN2O
by: Lu Zhi-Qiang
Published: (2022-08-01)

Crystal structure of (E)-4-(6-(4-(2-(pyridin-4-yl)vinyl)phenoxy)pyrimidin-4-yl)morpholine, C21H20N4O2
by: Bai Su-Fen, et al.
Published: (2022-08-01)

Crystal structure of 3-(3-bromophenyl)-1′,3′-dimethyl-2′H,3H,4H-spiro[furo[3, 2-c]chromene-2,5′-pyrimidine]-2′,4,4′,6′(1′H,3′H) tetraone, C22H15BrN2O6
by: Jiang Dong-Li, et al.
Published: (2022-08-01)

Asymmetric Donor–Acceptor 2,7-Disubstituted Fluorenes and Their 9-Diazoderivatives: Synthesis, Optical Spectra and Photolysis
by: Andrei I. Savchenko, et al.
Published: (2025-01-01)

Editorial Vol6 no2
by: Irene Stevens
Published: (2007-08-01)

The crystal structure of fac-tricarbonyl(6-bromo-2,2-bipyridine-κ2 N,N)-(nitrato-κO)rhenium(I), C13H7BrN3O6Re
by: Mkhatshwa Marcus, et al.
Published: (2023-08-01)

Synthesis of 4,7,9-Trihydroxy[1]benzofuro[3,2-d]pyrimidine-6-carboxamide: Evaluation of Cytotoxicity and Inhibition of Protein Kinase C (CaPkc1)
by: Dao Viet Hung, et al.
Published: (2021-01-01)

Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents
by: Niti Bhardwaj, et al.
Published: (2009-01-01)

Crystal structure of (3R,3aS,6R,6aR)-6-hexyl-3-methyltetrahydrofuro[3,4-b]furan-2,4-dione, C13H20O4
by: Huang Yu-Xi, et al.
Published: (2023-08-01)

Acid-decorated chitosan-magnetic aluminum ferrite as a bionanocomposite catalyst for green synthesis of biologically active [4,3‑d]pyrido[1,2‑a]pyrimidin-6‑ones
by: Maryam Saberi-Zare, et al.
Published: (2025-01-01)

Crystal structure of 1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene-N,N′-bis(1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-1,3,2-diazaborol-2-yl)-l2-germenediamine, C63H94B2GeN8
by: Wang Bing, et al.
Published: (2023-10-01)

Synthesis and Characterization of Oxidovanadium(IV) Complexes of 2-((E)-(6-Fluorobenzo[d]thiazol-2-ylimino)methyl)-6-methoxyphenol and Their Antimicrobial, Antioxidant, and DNA-Binding Studies
by: K. Savithri, et al.
Published: (2018-01-01)

The love for the poor neighbour: in memory of her (Matthew 26:6-13)
by: A. G. van Aarde
Published: (2016-06-01)

Melamine Trisulfonic Acid: An Efficient, Heterogeneous and Reusable Catalyst for the Synthesis of 10-Aryl-6,8-dimethyl- 6, 10-dihydro-5-oxa-6,8-diazaanthra [2,3-d][1,3]dioxole- 7,9-diones
by: Weilin Li, et al.
Published: (2011-01-01)

Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N3,N3′-Bis(disubstituted)isophthalyl-bis(thioureas) and Their Cu(II) and Ni(II) Complexes
by: Muhammad Jamil, et al.
Published: (2013-01-01)

Studies on Synthesis of Pyrimidine Derivatives and their Pharmacological Evaluation
by: T. A. Naik, et al.
Published: (2007-01-01)

Crystal structure of 10-methoxy-7,11b,12,13-tetrahydro-6H-pyrazino [2′,3′:5,6]pyrazino[2,1-a]isoquinoline, C15H16N4O
by: Wang Zi Wei, et al.
Published: (2023-10-01)

Crystal structure of 4-(2,2-difluoroethyl)-2,4-dimethyl-6-(trifluoromethyl)isoquinoline-1,3(2H,4H)-dione, C14H12F5NO2
by: Liu Jianlian, et al.
Published: (2021-09-01)

The crystal structure of bis(pyrazolo[1,5-a]pyrimidine-3-carboxylato-κ2N,O)-copper(ii), C14H8N6O4Cu
by: Hong Dong-Feng, et al.
Published: (2022-08-01)

Synergistic Fire Retardancy of Bis(1-methoxy-2,2,6,6-tetramethylpiperidin-4-yl)sebacate and Tris(2,4,6-tribromophenoxy)-1,3,5-triazine/Sb2O3 in HIPS
by: Hongzhi Wu, et al.
Published: (2020-01-01)

A critical analysis of Purnomo and colleagues’ interpretation in Matthew 6:9–13
by: Harman Z. Laia, et al.
Published: (2025-01-01)

Molecular Iodine: A Versatile Catalyst for the Synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione Derivatives in Ethanol
by: Xiao Wang, et al.
Published: (2011-01-01)

The crystal structure of 6-bromohexanoic acid, C6H11BrO2
by: Ndima Lubabalo, et al.
Published: (2021-09-01)