Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial Agents
A new series of 1,3-pyrimidine derivatives (3a-f) have been synthesized by reacting 2,4,6-Trichloropyrimidine with nucleophilic reagents 2-amino-6-fluorobenzothiazole (1) in the presence of acetone. The (4,6- dichloro-pyrimidin-2-yl)-amine (2) so produced was then reacted to two moles of phenylthi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/820718 |
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| author | Anoop K. Pathak Viney Chawla Shailendra K. Saraf |
| author_facet | Anoop K. Pathak Viney Chawla Shailendra K. Saraf |
| author_sort | Anoop K. Pathak |
| collection | DOAJ |
| description | A new series of 1,3-pyrimidine derivatives (3a-f) have been synthesized by reacting 2,4,6-Trichloropyrimidine with nucleophilic reagents 2-amino-6-fluorobenzothiazole (1) in the presence of acetone. The (4,6- dichloro-pyrimidin-2-yl)-amine (2) so produced was then reacted to two moles of phenylthiourea derivatives to yield title compounds (3a-f). The structural assessment of the compounds (3a-f) was made on the basis of spectral data. The synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria viz., B. subtilis, E. coli, P. aeruginosa and S. aureus using agar diffusion technique. Compounds 3c and 3f exhibited highest antibacterial activity. |
| format | Article |
| id | doaj-art-19db9a17700145d59e1a5aa88c61a7c5 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-19db9a17700145d59e1a5aa88c61a7c52025-02-03T01:30:18ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-018124024410.1155/2011/820718Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial AgentsAnoop K. Pathak0Viney Chawla1Shailendra K. Saraf2Faculty of Pharmacy, Northern India Engineering College Sector-2, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow-227105, IndiaFaculty of Pharmacy, Northern India Engineering College Sector-2, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow-227105, IndiaFaculty of Pharmacy, Northern India Engineering College Sector-2, Dr. Akhilesh Das Nagar, Faizabad Road, Lucknow-227105, IndiaA new series of 1,3-pyrimidine derivatives (3a-f) have been synthesized by reacting 2,4,6-Trichloropyrimidine with nucleophilic reagents 2-amino-6-fluorobenzothiazole (1) in the presence of acetone. The (4,6- dichloro-pyrimidin-2-yl)-amine (2) so produced was then reacted to two moles of phenylthiourea derivatives to yield title compounds (3a-f). The structural assessment of the compounds (3a-f) was made on the basis of spectral data. The synthesized compounds were screened for their in vitro growth inhibiting activity against different strains of bacteria viz., B. subtilis, E. coli, P. aeruginosa and S. aureus using agar diffusion technique. Compounds 3c and 3f exhibited highest antibacterial activity.http://dx.doi.org/10.1155/2011/820718 |
| spellingShingle | Anoop K. Pathak Viney Chawla Shailendra K. Saraf Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial Agents E-Journal of Chemistry |
| title | Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial Agents |
| title_full | Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial Agents |
| title_fullStr | Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial Agents |
| title_full_unstemmed | Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial Agents |
| title_short | Syntheses of 2-(6’-Fluorobenzothiazol-2’-ylamino)-4, 6-(disubstituted thiouriedo)-1,3-pyrimidine Derivatives as Antimicrobial Agents |
| title_sort | syntheses of 2 6 fluorobenzothiazol 2 ylamino 4 6 disubstituted thiouriedo 1 3 pyrimidine derivatives as antimicrobial agents |
| url | http://dx.doi.org/10.1155/2011/820718 |
| work_keys_str_mv | AT anoopkpathak synthesesof26fluorobenzothiazol2ylamino46disubstitutedthiouriedo13pyrimidinederivativesasantimicrobialagents AT vineychawla synthesesof26fluorobenzothiazol2ylamino46disubstitutedthiouriedo13pyrimidinederivativesasantimicrobialagents AT shailendraksaraf synthesesof26fluorobenzothiazol2ylamino46disubstitutedthiouriedo13pyrimidinederivativesasantimicrobialagents |