Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases
We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmap...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2016/4391537 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555259090698240 |
|---|---|
| author | Valeria Muller Ksenia Ob’edkova Inna Krikheli Igor Kogan Irina Fedorova Elena Lesik Evgenia Komarova Alexandr Gzgzyan |
| author_facet | Valeria Muller Ksenia Ob’edkova Inna Krikheli Igor Kogan Irina Fedorova Elena Lesik Evgenia Komarova Alexandr Gzgzyan |
| author_sort | Valeria Muller |
| collection | DOAJ |
| description | We report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. No adverse side effects were observed; all cases resulted in pregnancy and subsequent life births. In order to be given an adequate efficient treatment, women with recurrent implantation failure should be suspected for autoimmune factor of infertility and its possible association with anti-hCG autoimmunity. |
| format | Article |
| id | doaj-art-19cfa272685c4d57b5a52053eb65e0b1 |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-19cfa272685c4d57b5a52053eb65e0b12025-02-03T05:48:38ZengWileyCase Reports in Immunology2090-66092090-66172016-01-01201610.1155/2016/43915374391537Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three CasesValeria Muller0Ksenia Ob’edkova1Inna Krikheli2Igor Kogan3Irina Fedorova4Elena Lesik5Evgenia Komarova6Alexandr Gzgzyan7Department of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaDepartment of Assisted Reproduction Technologies, FSBI D. O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, RussiaWe report three cases of effective management of infertility in women with a history of repeated unsuccessful IVF attempts, who have developed antibodies to hCG. A novel approach to conservative treatment of immunologic reproductive failure, suggested for selected patients, included membrane plasmapheresis, combined prednisolone, and intravenous immunoglobulin therapy. No adverse side effects were observed; all cases resulted in pregnancy and subsequent life births. In order to be given an adequate efficient treatment, women with recurrent implantation failure should be suspected for autoimmune factor of infertility and its possible association with anti-hCG autoimmunity.http://dx.doi.org/10.1155/2016/4391537 |
| spellingShingle | Valeria Muller Ksenia Ob’edkova Inna Krikheli Igor Kogan Irina Fedorova Elena Lesik Evgenia Komarova Alexandr Gzgzyan Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases Case Reports in Immunology |
| title | Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases |
| title_full | Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases |
| title_fullStr | Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases |
| title_full_unstemmed | Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases |
| title_short | Successful Pregnancy Outcome in Women with Recurrent IVF Failure and Anti-hCG Autoimmunity: A Report of Three Cases |
| title_sort | successful pregnancy outcome in women with recurrent ivf failure and anti hcg autoimmunity a report of three cases |
| url | http://dx.doi.org/10.1155/2016/4391537 |
| work_keys_str_mv | AT valeriamuller successfulpregnancyoutcomeinwomenwithrecurrentivffailureandantihcgautoimmunityareportofthreecases AT kseniaobedkova successfulpregnancyoutcomeinwomenwithrecurrentivffailureandantihcgautoimmunityareportofthreecases AT innakrikheli successfulpregnancyoutcomeinwomenwithrecurrentivffailureandantihcgautoimmunityareportofthreecases AT igorkogan successfulpregnancyoutcomeinwomenwithrecurrentivffailureandantihcgautoimmunityareportofthreecases AT irinafedorova successfulpregnancyoutcomeinwomenwithrecurrentivffailureandantihcgautoimmunityareportofthreecases AT elenalesik successfulpregnancyoutcomeinwomenwithrecurrentivffailureandantihcgautoimmunityareportofthreecases AT evgeniakomarova successfulpregnancyoutcomeinwomenwithrecurrentivffailureandantihcgautoimmunityareportofthreecases AT alexandrgzgzyan successfulpregnancyoutcomeinwomenwithrecurrentivffailureandantihcgautoimmunityareportofthreecases |