Delayed-Onset Seizure in a Mild Quetiapine Overdose: Report of a Case and Review of the Literature
Among atypical antipsychotics, quetiapine is commonly prescribed and considered to have a favorable side effect and safety profile. Here, we report the case of a patient who developed a generalized tonic-clonic seizure 28 hours following ingestion of 1,400 mg of quetiapine. Review of the literature...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2018/7623051 |
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| _version_ | 1832568338883018752 |
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| author | Jason A. Chen Katherine M. Unverferth Erick H. Cheung |
| author_facet | Jason A. Chen Katherine M. Unverferth Erick H. Cheung |
| author_sort | Jason A. Chen |
| collection | DOAJ |
| description | Among atypical antipsychotics, quetiapine is commonly prescribed and considered to have a favorable side effect and safety profile. Here, we report the case of a patient who developed a generalized tonic-clonic seizure 28 hours following ingestion of 1,400 mg of quetiapine. Review of the literature identifies delayed-onset seizure as a potential complication of quetiapine overdose. Unique to this case, delayed-onset seizures occurred in a patient with a relatively low dose of quetiapine and no obvious toxidrome, suggesting that this reaction may be an important consideration in the management of quetiapine overdose. The pharmacokinetics and pharmacodynamics of quetiapine may explain this unusual phenomenon. |
| format | Article |
| id | doaj-art-19ccf05c890c4edaa1a6dff897c4513f |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-19ccf05c890c4edaa1a6dff897c4513f2025-02-03T00:59:15ZengWileyCase Reports in Psychiatry2090-682X2090-68382018-01-01201810.1155/2018/76230517623051Delayed-Onset Seizure in a Mild Quetiapine Overdose: Report of a Case and Review of the LiteratureJason A. Chen0Katherine M. Unverferth1Erick H. Cheung2Department of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USADepartment of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USADepartment of Psychiatry and Biobehavioral Sciences, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USAAmong atypical antipsychotics, quetiapine is commonly prescribed and considered to have a favorable side effect and safety profile. Here, we report the case of a patient who developed a generalized tonic-clonic seizure 28 hours following ingestion of 1,400 mg of quetiapine. Review of the literature identifies delayed-onset seizure as a potential complication of quetiapine overdose. Unique to this case, delayed-onset seizures occurred in a patient with a relatively low dose of quetiapine and no obvious toxidrome, suggesting that this reaction may be an important consideration in the management of quetiapine overdose. The pharmacokinetics and pharmacodynamics of quetiapine may explain this unusual phenomenon.http://dx.doi.org/10.1155/2018/7623051 |
| spellingShingle | Jason A. Chen Katherine M. Unverferth Erick H. Cheung Delayed-Onset Seizure in a Mild Quetiapine Overdose: Report of a Case and Review of the Literature Case Reports in Psychiatry |
| title | Delayed-Onset Seizure in a Mild Quetiapine Overdose: Report of a Case and Review of the Literature |
| title_full | Delayed-Onset Seizure in a Mild Quetiapine Overdose: Report of a Case and Review of the Literature |
| title_fullStr | Delayed-Onset Seizure in a Mild Quetiapine Overdose: Report of a Case and Review of the Literature |
| title_full_unstemmed | Delayed-Onset Seizure in a Mild Quetiapine Overdose: Report of a Case and Review of the Literature |
| title_short | Delayed-Onset Seizure in a Mild Quetiapine Overdose: Report of a Case and Review of the Literature |
| title_sort | delayed onset seizure in a mild quetiapine overdose report of a case and review of the literature |
| url | http://dx.doi.org/10.1155/2018/7623051 |
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