Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer
Lung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/6319649 |
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| _version_ | 1832549978996736000 |
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| author | Jie Ma Huaxi Xu Shengjun Wang |
| author_facet | Jie Ma Huaxi Xu Shengjun Wang |
| author_sort | Jie Ma |
| collection | DOAJ |
| description | Lung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs is gradually emerging. In this review, we summarize what is currently known about the role of MDSCs in lung cancer. In view of the emerging importance of MDSCs in lung cancer, the treatment of targeting MDSCs will be useful to the control of the development and progression of lung cancer. However, the occurrence, metastasis, and survival of cancer is the result of multiple factors and multiple mechanisms, so combined treatments using different strategies will become the major therapy method for lung cancer in the future. |
| format | Article |
| id | doaj-art-19c987759a054827b0b497e4a4404e33 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-19c987759a054827b0b497e4a4404e332025-02-03T06:07:56ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/63196496319649Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung CancerJie Ma0Huaxi Xu1Shengjun Wang2Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, ChinaInstitute of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, ChinaLung cancer is the leading cause of cancer death worldwide due to its late diagnosis and poor outcome. Immunotherapy is becoming more and more encouraging and promising in lung cancer therapy. Myeloid-derived suppressor cells (MDSCs) are the main tumor suppressor factors, and the treatment strategy of targeting MDSCs is gradually emerging. In this review, we summarize what is currently known about the role of MDSCs in lung cancer. In view of the emerging importance of MDSCs in lung cancer, the treatment of targeting MDSCs will be useful to the control of the development and progression of lung cancer. However, the occurrence, metastasis, and survival of cancer is the result of multiple factors and multiple mechanisms, so combined treatments using different strategies will become the major therapy method for lung cancer in the future.http://dx.doi.org/10.1155/2018/6319649 |
| spellingShingle | Jie Ma Huaxi Xu Shengjun Wang Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer Journal of Immunology Research |
| title | Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer |
| title_full | Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer |
| title_fullStr | Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer |
| title_full_unstemmed | Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer |
| title_short | Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer |
| title_sort | immunosuppressive role of myeloid derived suppressor cells and therapeutic targeting in lung cancer |
| url | http://dx.doi.org/10.1155/2018/6319649 |
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