Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study
Purpose. To describe changes in the retina and choroidal flow by optical coherence tomography angiography (OCT-A) after a single dose of oral sildenafil. Method. A case-control study. Patients in the study group received 50 mg of oral sildenafil. Patients in the control group received a sham pill. R...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/7174540 |
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| author | David Berrones Guillermo Salcedo-Villanueva Virgilio Morales-Cantón Raul Velez-Montoya |
| author_facet | David Berrones Guillermo Salcedo-Villanueva Virgilio Morales-Cantón Raul Velez-Montoya |
| author_sort | David Berrones |
| collection | DOAJ |
| description | Purpose. To describe changes in the retina and choroidal flow by optical coherence tomography angiography (OCT-A) after a single dose of oral sildenafil. Method. A case-control study. Patients in the study group received 50 mg of oral sildenafil. Patients in the control group received a sham pill. Retinal and choroidal images were obtained at baseline (before pill ingestion) and 1 hour after ingestion. Central macular and choroidal thickness, choroidal and outer retina flow, and the retinal and choroidal vascular density were compared using a Mann-Whitney U test. Results. Twenty eyes were enrolled into the study group and 10 eyes in the control group. There was a significant difference in central choroidal thickness and outer retina blood flow between groups after 1 hour of sildenafil ingestion (p<0.01). There were no differences in central macular thickness, choroidal flow, and retinal vascular density among groups. Conclusions. A single dose of oral sildenafil increases choroidal thickness, probably due to sildenafil-induced vasodilation. |
| format | Article |
| id | doaj-art-19c3e241885a4b2e9947ee5a2c53281f |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-19c3e241885a4b2e9947ee5a2c53281f2025-02-03T05:46:12ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/71745407174540Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography StudyDavid Berrones0Guillermo Salcedo-Villanueva1Virgilio Morales-Cantón2Raul Velez-Montoya3Ophthalmology Department, Asociación para Evitar la Ceguera en México IAP, Mexico City, MexicoRetina Department, Asociación para Evitar la Ceguera en México IAP, Mexico City, MexicoRetina Department, Asociación para Evitar la Ceguera en México IAP, Mexico City, MexicoRetina Department, Asociación para Evitar la Ceguera en México IAP, Mexico City, MexicoPurpose. To describe changes in the retina and choroidal flow by optical coherence tomography angiography (OCT-A) after a single dose of oral sildenafil. Method. A case-control study. Patients in the study group received 50 mg of oral sildenafil. Patients in the control group received a sham pill. Retinal and choroidal images were obtained at baseline (before pill ingestion) and 1 hour after ingestion. Central macular and choroidal thickness, choroidal and outer retina flow, and the retinal and choroidal vascular density were compared using a Mann-Whitney U test. Results. Twenty eyes were enrolled into the study group and 10 eyes in the control group. There was a significant difference in central choroidal thickness and outer retina blood flow between groups after 1 hour of sildenafil ingestion (p<0.01). There were no differences in central macular thickness, choroidal flow, and retinal vascular density among groups. Conclusions. A single dose of oral sildenafil increases choroidal thickness, probably due to sildenafil-induced vasodilation.http://dx.doi.org/10.1155/2017/7174540 |
| spellingShingle | David Berrones Guillermo Salcedo-Villanueva Virgilio Morales-Cantón Raul Velez-Montoya Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study Journal of Ophthalmology |
| title | Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study |
| title_full | Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study |
| title_fullStr | Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study |
| title_full_unstemmed | Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study |
| title_short | Changes in Retinal and Choroidal Vascular Blood Flow after Oral Sildenafil: An Optical Coherence Tomography Angiography Study |
| title_sort | changes in retinal and choroidal vascular blood flow after oral sildenafil an optical coherence tomography angiography study |
| url | http://dx.doi.org/10.1155/2017/7174540 |
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