TOPK promotes immune suppression in kidney renal clear cell carcinoma and emerges as a prognostic and therapeutic target

TOPK promotes immune suppression in kidney renal clear cell carcinoma and emerges as a prognostic and therapeutic target

Abstract The T-LAK cell-originated protein kinase (TOPK) has been associated with poor prognosis in various cancers, yet its specific role in kidney renal clear cell carcinoma (KIRC) remains unclear. In this study, we conducted a comprehensive investigation of TOPK expression and its association wit...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zeyuan Zheng, Renhui Xiong, Xiuyuan Sui, Liyan Li, Huimin Sun, Chen Shao
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Series:	BMC Cancer
Subjects:	T-LAK cell-originated protein kinase (TOPK) Tumor microenvironment (TME) Biomarkers Immunotherapy Kidney Renal Clear Cell Carcinoma (KIRC)
Online Access:	https://doi.org/10.1186/s12885-025-14665-0
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Correlation study of PBK/TOPK expression, prognosis, and immune infiltration in breast cancer
by: Bingxin Li, et al.
Published: (2025-04-01)

Identification of kidney renal clear cell carcinoma prognosis based on gene expression and clinical information
by: Xiong Zou, et al.
Published: (2025-08-01)

Discovery of novel paeonol-based derivatives against skin inflammation in vitro and in vivo
by: Jing Wu, et al.
Published: (2022-12-01)

A novel glycogene-related signature for prognostic prediction and immune microenvironment assessment in kidney renal clear cell carcinoma
by: Xuyan Zhao, et al.
Published: (2025-12-01)

Construction of a risk and prognostic model for migrasome-associated lncRNAs in renal cell carcinoma
by: Liangwei Zhao, et al.
Published: (2025-07-01)

Correlation study of LINC02609 and SNHG17 as prognostic biomarkers of kidney renal clear cell carcinoma and therapeutic sensitivity based on public data and In Vitro analysis
by: Chaoqun Xing, et al.
Published: (2025-05-01)

Cancer-associated fibroblasts in clear cell renal cell carcinoma: functional heterogeneity, tumor microenvironment crosstalk, and therapeutic opportunities
by: Man Wang, et al.
Published: (2025-06-01)

Unveiling tumor-infiltrating immune cell-driven immune-mediated drug resistance in clear cell renal cell carcinoma: prognostic insights and therapeutic strategies
by: Jifeng Yang, et al.
Published: (2025-03-01)

Arginine methylation modulates tumor fate and prognosis in clear cell renal cell carcinoma
by: Jiahao Wang, et al.
Published: (2025-05-01)

CTSS in the tumor microenvironment links immune escape and immunotherapy sensitivity in kidney renal clear cell carcinoma
by: Hanjing Zhou, et al.
Published: (2025-07-01)

Investigating the molecular mechanisms and clinical potential of APO+ endothelial cells associated with PANoptosis in the tumor microenvironment of hepatocellular carcinoma using single-cell sequencing data
by: Zhaorui Cheng, et al.
Published: (2025-07-01)

Comprehensive analysis of α2,3-sialyltransferases as prognostic biomarkers and immunotherapy targets in kidney renal clear cell carcinoma
by: Yuli Jian, et al.
Published: (2025-02-01)

T cell subsets in cervical cancer tumor microenvironment: advances and therapeutic opportunities
by: Weilin Guo, et al.
Published: (2025-06-01)

Epithelial and macrophage cell interaction in cervical cancer through single-cell RNA-sequencing and spatial analysis
by: Zhichao Wang, et al.
Published: (2025-04-01)

ALDOB is a prognostic biomarker and a potential immunotherapy target for clear cell renal cell carcinoma
by: Wu Xu, et al.
Published: (2025-08-01)

Integrating machine learning and multi-omics analysis to unveil key programmed cell death patterns and immunotherapy targets in kidney renal clear cell carcinoma
by: Fanyan Ou, et al.
Published: (2025-05-01)

Prognostic and therapeutic relevance of IL2RG-related LncRNAs in clear cell renal cell carcinoma
by: Weijing Hu, et al.
Published: (2025-08-01)

TERT promoter methylation predicts overall survival, immune cell infiltration and response to immunotherapy in clear cell renal cell carcinoma
by: Xinyu Guan, et al.
Published: (2025-05-01)

Integrative analysis of cholesterol homeostasis reveals prognostic subtypes and immune features in clear cell renal cell carcinoma
by: Jian Zhu, et al.
Published: (2025-07-01)

Exploring the prognostic role and expression patterns of FAM3A family genes in kidney renal clear cell carcinoma
by: Shoaib Muhammad, et al.
Published: (2025-07-01)

Prognostic and Therapeutic Implications of Alamandine Receptor MrgD Expression in Clear Cell Renal Cell Carcinoma with Development of Metastatic Disease
by: Gorka Larrinaga, et al.
Published: (2025-03-01)

Single-cell technologies and spatial transcriptomics: decoding immune low - response states in endometrial cancer
by: Yumeng Li, et al.
Published: (2025-07-01)

Editorial: Community series in cell network in antitumor immunity of pediatric and adult solid tumors, volume II
by: Ombretta Melaiu, et al.
Published: (2025-06-01)

Identifying a prognostic signature for clear cell renal cell carcinoma: the convergence of single-cell and bulk sequencing with machine learning
by: Yude Hong, et al.
Published: (2025-06-01)

Analysis of immune status and prognostic model incorporating lactate metabolism and immune-related genes in clear cell renal cell carcinoma
by: Jun Wu, et al.
Published: (2025-06-01)

Treatment results and prognostic factors of clear cell ovarian carcinomas and ovarian carcinomas with clear cell component
by: M. D. Ahmedova, et al.
Published: (2014-07-01)

Multi-omics analysis of zinc finger protein 683 as a prognostic biomarker for immune infiltration in clear cell renal cell carcinoma
by: Yicheng Guo, et al.
Published: (2025-07-01)

Mitophagy related gene signature for prognosis and therapeutic evaluation in KIRC
by: Dengyi Duan, et al.
Published: (2025-07-01)

FOXM1 could serve as a bridge mediating prognosis and immunity for clear cell renal cell carcinoma via single-cell and bulk RNA-sequencing
by: Jianhua Zhou, et al.
Published: (2025-04-01)

Prognostic related signature predicts the benefits of immunotherapy for kidney renal clear cell carcinoma
by: Feng Xiong, et al.
Published: (2025-06-01)

Overcoming immunotherapy resistance in glioblastoma: challenges and emerging strategies
by: Maowu Fu, et al.
Published: (2025-03-01)

Reprogramming the tumor-immune landscape via nanomaterial-induced immunogenic cell death: a mini review
by: Xiangwei Meng, et al.
Published: (2025-07-01)

Efficacy and safety of Tislelizumab combined with Axitinib as first-line treatment for intermediate- and high-risk metastatic clear-cell renal cell carcinoma
by: Jie Cui, et al.
Published: (2025-05-01)

Sialyltransferase gene signature as a predictor of prognosis and therapeutic response in kidney renal clear cell carcinoma
by: Huiyu Liu, et al.
Published: (2025-05-01)

Angiogenesis related gene signatures predict prognosis and guide therapeutic strategies in renal clear cell carcinoma
by: Yuhe Zhou, et al.
Published: (2025-05-01)

Metabolic reprogramming and immune microenvironment profiling in clear cell renal cell carcinoma: implications for prognosis, targeted therapy, and drug resistance
by: Xiao Zheng, et al.
Published: (2025-05-01)

Comprehensive analysis of the leukocyte immunoglobulin-like receptor family in clear cell renal cell carcinoma
by: He Wei, et al.
Published: (2025-12-01)

Identification and Experimental Validation of Prognostic Signature and Peroxisome-Related Key Genes in Clear Cell Renal Cell Carcinoma
by: Fan C, et al.
Published: (2025-05-01)

Immunotherapy biomarkers in brain metastases: insights into tumor microenvironment dynamics
by: Mu Li, et al.
Published: (2025-08-01)

The pivotal role of tertiary lymphoid structures in the tumor immune microenvironment
by: Chengsen Liu, et al.
Published: (2025-05-01)