The causes of dysregulation of immune response in pulmonary tuberculosis: the impact of M. tuberculosis on the course of immune response
The most plausible formation mechanisms of the secondary immunologic insufficiency and dysregulation of immune response to M. tuberculosis in relation to the biologic specificities of the infectious agent are discussed in this review. The ability of M. tuberculosis to affect the activity of antigen-...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2012-06-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/499 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849241086725193728 |
|---|---|
| author | I. Ye. Yesimova O. I. Urazova V. V. Novitsky R. R. Hasanova A. A. Koshkina Ye. G. Churina |
| author_facet | I. Ye. Yesimova O. I. Urazova V. V. Novitsky R. R. Hasanova A. A. Koshkina Ye. G. Churina |
| author_sort | I. Ye. Yesimova |
| collection | DOAJ |
| description | The most plausible formation mechanisms of the secondary immunologic insufficiency and dysregulation of immune response to M. tuberculosis in relation to the biologic specificities of the infectious agent are discussed in this review. The ability of M. tuberculosis to affect the activity of antigen-presenting cells and T-lymphocytes, which manifests itself in disbalance of pro- and anti-inflammatory cytokines and the expression of the basic molecules of intercellular cooperation, the activation of the suppressing mechanisms and apoptosis resulting in immune hypo- and anergy of T-lymphocytes and the disorder of effective immune response formation in general, is also described. |
| format | Article |
| id | doaj-art-19a57b0f8dd24876b6a833e7ddb33169 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2012-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-19a57b0f8dd24876b6a833e7ddb331692025-08-20T04:00:18ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842012-06-01113798610.20538/1682-0363-2012-3-79-86471The causes of dysregulation of immune response in pulmonary tuberculosis: the impact of M. tuberculosis on the course of immune responseI. Ye. Yesimova0O. I. Urazova1V. V. Novitsky2R. R. Hasanova3A. A. Koshkina4Ye. G. Churina5Сибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскСибирский государственный медицинский университет, г. ТомскThe most plausible formation mechanisms of the secondary immunologic insufficiency and dysregulation of immune response to M. tuberculosis in relation to the biologic specificities of the infectious agent are discussed in this review. The ability of M. tuberculosis to affect the activity of antigen-presenting cells and T-lymphocytes, which manifests itself in disbalance of pro- and anti-inflammatory cytokines and the expression of the basic molecules of intercellular cooperation, the activation of the suppressing mechanisms and apoptosis resulting in immune hypo- and anergy of T-lymphocytes and the disorder of effective immune response formation in general, is also described.https://bulletin.ssmu.ru/jour/article/view/499pulmonary tuberculosissecondary immunological insufficiencyantigen-presenting cellst-lymphocytescytokinesapoptosis |
| spellingShingle | I. Ye. Yesimova O. I. Urazova V. V. Novitsky R. R. Hasanova A. A. Koshkina Ye. G. Churina The causes of dysregulation of immune response in pulmonary tuberculosis: the impact of M. tuberculosis on the course of immune response Бюллетень сибирской медицины pulmonary tuberculosis secondary immunological insufficiency antigen-presenting cells t-lymphocytes cytokines apoptosis |
| title | The causes of dysregulation of immune response in pulmonary tuberculosis: the impact of M. tuberculosis on the course of immune response |
| title_full | The causes of dysregulation of immune response in pulmonary tuberculosis: the impact of M. tuberculosis on the course of immune response |
| title_fullStr | The causes of dysregulation of immune response in pulmonary tuberculosis: the impact of M. tuberculosis on the course of immune response |
| title_full_unstemmed | The causes of dysregulation of immune response in pulmonary tuberculosis: the impact of M. tuberculosis on the course of immune response |
| title_short | The causes of dysregulation of immune response in pulmonary tuberculosis: the impact of M. tuberculosis on the course of immune response |
| title_sort | causes of dysregulation of immune response in pulmonary tuberculosis the impact of m tuberculosis on the course of immune response |
| topic | pulmonary tuberculosis secondary immunological insufficiency antigen-presenting cells t-lymphocytes cytokines apoptosis |
| url | https://bulletin.ssmu.ru/jour/article/view/499 |
| work_keys_str_mv | AT iyeyesimova thecausesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT oiurazova thecausesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT vvnovitsky thecausesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT rrhasanova thecausesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT aakoshkina thecausesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT yegchurina thecausesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT iyeyesimova causesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT oiurazova causesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT vvnovitsky causesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT rrhasanova causesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT aakoshkina causesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse AT yegchurina causesofdysregulationofimmuneresponseinpulmonarytuberculosistheimpactofmtuberculosisonthecourseofimmuneresponse |