Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain Shift
<b>Background</b>: Elastic image fusion (EIF) using an intraoperative CT (iCT) scan may enhance neuronavigation accuracy and compensate for brain shift. <b>Objective</b>: To evaluate the safety and reliability of the EIF algorithm (Virtual iMRI Cranial 4.5, Brainlab AG, Munic...
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2024-12-01
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| author | Erica Grasso Francesco Certo Mario Ganau Giulio Bonomo Giuseppa Fiumanò Giovanni Buscema Andrea Maugeri Antonella Agodi Giuseppe M. V. Barbagallo |
| author_facet | Erica Grasso Francesco Certo Mario Ganau Giulio Bonomo Giuseppa Fiumanò Giovanni Buscema Andrea Maugeri Antonella Agodi Giuseppe M. V. Barbagallo |
| author_sort | Erica Grasso |
| collection | DOAJ |
| description | <b>Background</b>: Elastic image fusion (EIF) using an intraoperative CT (iCT) scan may enhance neuronavigation accuracy and compensate for brain shift. <b>Objective</b>: To evaluate the safety and reliability of the EIF algorithm (Virtual iMRI Cranial 4.5, Brainlab AG, Munich Germany, for the identification of residual tumour in glioblastoma surgery. Moreover, the impact of brain shift on software reliability is assessed. <b>Methods</b>: This ambispective study included 80 patients with a diagnosis of glioblastoma. Pre-operative MRI was elastically fused with an intraoperative CT scan (BodyTom; Samsung-Neurologica, Danvers, MA, USA) acquired at the end of the resection. Diagnostic specificity and the sensitivity of each tool was determined. The impact of brain shift on residual tumour was statistically analysed. An analysis of accuracy was performed through Target Registration Error (TRE) measurement after rigid image fusion (RIF) and EIF. A qualitative evaluation of each Virtual MRI image (VMRI) was performed. <b>Results</b>: VMRI identified residual tumour in 26/80 patients (32.5%), confirmed by post-operative MRI (true positive). Of these, 5 cases were left intentionally due to DES-positive responses, 8 cases underwent near maximal or subtotal resection, and 13 cases were not detected by iCT. However, in the other 27/80 cases (33.8%), VMRI reported residual tumour that was present neither on iCT nor on post-operative MRI (false positive). i-CT showed a sensitivity of 56% and specificity of 100%; VMRI demonstrated a sensitivity of 100% and specificity of 50%. Spearman correlation analysis showed a moderate correlation between pre-operative volume and VMRI tumour residual. Moreover, tumour involving insula or infiltrating more than one lobe displayed higher median values (<i>p</i> = 0.023) of virtual residual tumour. A statistically significant reduction towards lower TRE values after EIF was observed for test structures. <b>Conclusions</b>: Virtual iMRI was proven to be a feasible option to detect residual tumour. Its integration within a multimodal imaging protocol may provide neurosurgeons with intraoperatively updated imaging. |
| format | Article |
| id | doaj-art-19a2894c13734ed79e42fb717ba59ae6 |
| institution | Kabale University |
| issn | 2076-3425 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Brain Sciences |
| spelling | doaj-art-19a2894c13734ed79e42fb717ba59ae62025-01-24T13:25:45ZengMDPI AGBrain Sciences2076-34252024-12-011513510.3390/brainsci15010035Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain ShiftErica Grasso0Francesco Certo1Mario Ganau2Giulio Bonomo3Giuseppa Fiumanò4Giovanni Buscema5Andrea Maugeri6Antonella Agodi7Giuseppe M. V. Barbagallo8Department of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Neurological Surgery, Policlinico “G. Rodolico-San Marco” University Hospital, University of Catania, 95124 Catania, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Neurological Surgery, Policlinico “G. Rodolico-San Marco” University Hospital, University of Catania, 95124 Catania, ItalyNuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX1 2JD, UKDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Neurological Surgery, Policlinico “G. Rodolico-San Marco” University Hospital, University of Catania, 95124 Catania, ItalyDepartment of Radiology and Radiotherapy, Policlinico “G. Rodolico-San Marco” University Hospital, University of Catania, 95124 Catania, ItalyDepartment of Anesthesia and Intensive Care, University Hospital Policlinico “G. Rodolico-San Marco”, 95123 Catania, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95124 Catania, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, University of Catania, 95124 Catania, ItalyDepartment of Medical and Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Neurological Surgery, Policlinico “G. Rodolico-San Marco” University Hospital, University of Catania, 95124 Catania, Italy<b>Background</b>: Elastic image fusion (EIF) using an intraoperative CT (iCT) scan may enhance neuronavigation accuracy and compensate for brain shift. <b>Objective</b>: To evaluate the safety and reliability of the EIF algorithm (Virtual iMRI Cranial 4.5, Brainlab AG, Munich Germany, for the identification of residual tumour in glioblastoma surgery. Moreover, the impact of brain shift on software reliability is assessed. <b>Methods</b>: This ambispective study included 80 patients with a diagnosis of glioblastoma. Pre-operative MRI was elastically fused with an intraoperative CT scan (BodyTom; Samsung-Neurologica, Danvers, MA, USA) acquired at the end of the resection. Diagnostic specificity and the sensitivity of each tool was determined. The impact of brain shift on residual tumour was statistically analysed. An analysis of accuracy was performed through Target Registration Error (TRE) measurement after rigid image fusion (RIF) and EIF. A qualitative evaluation of each Virtual MRI image (VMRI) was performed. <b>Results</b>: VMRI identified residual tumour in 26/80 patients (32.5%), confirmed by post-operative MRI (true positive). Of these, 5 cases were left intentionally due to DES-positive responses, 8 cases underwent near maximal or subtotal resection, and 13 cases were not detected by iCT. However, in the other 27/80 cases (33.8%), VMRI reported residual tumour that was present neither on iCT nor on post-operative MRI (false positive). i-CT showed a sensitivity of 56% and specificity of 100%; VMRI demonstrated a sensitivity of 100% and specificity of 50%. Spearman correlation analysis showed a moderate correlation between pre-operative volume and VMRI tumour residual. Moreover, tumour involving insula or infiltrating more than one lobe displayed higher median values (<i>p</i> = 0.023) of virtual residual tumour. A statistically significant reduction towards lower TRE values after EIF was observed for test structures. <b>Conclusions</b>: Virtual iMRI was proven to be a feasible option to detect residual tumour. Its integration within a multimodal imaging protocol may provide neurosurgeons with intraoperatively updated imaging.https://www.mdpi.com/2076-3425/15/1/35brain shiftelastic image fusionglioblastomaintraoperative CTrigid image fusionVirtual iMRI |
| spellingShingle | Erica Grasso Francesco Certo Mario Ganau Giulio Bonomo Giuseppa Fiumanò Giovanni Buscema Andrea Maugeri Antonella Agodi Giuseppe M. V. Barbagallo Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain Shift Brain Sciences brain shift elastic image fusion glioblastoma intraoperative CT rigid image fusion Virtual iMRI |
| title | Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain Shift |
| title_full | Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain Shift |
| title_fullStr | Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain Shift |
| title_full_unstemmed | Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain Shift |
| title_short | Role of Virtual iMRI in Glioblastoma Surgery: Advantages, Limitations, and Correlation with iCT and Brain Shift |
| title_sort | role of virtual imri in glioblastoma surgery advantages limitations and correlation with ict and brain shift |
| topic | brain shift elastic image fusion glioblastoma intraoperative CT rigid image fusion Virtual iMRI |
| url | https://www.mdpi.com/2076-3425/15/1/35 |
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