Clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infection
Recently, the incidence and prevalence of NTM have been increasing nationwide in many countries. This study aimed to identify risk factors associated with the prognosis and mortality of non-HIV nontuberculous mycobacterial disease patients. This retrospective study was conducted at Peking Union Medi...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Virulence |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2025.2459313 |
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| author | Jinjing Chai Sujie Zhang Chong Ma Qimin Mei Tao Liu Jihai Liu Yecheng Liu Huadong Zhu |
| author_facet | Jinjing Chai Sujie Zhang Chong Ma Qimin Mei Tao Liu Jihai Liu Yecheng Liu Huadong Zhu |
| author_sort | Jinjing Chai |
| collection | DOAJ |
| description | Recently, the incidence and prevalence of NTM have been increasing nationwide in many countries. This study aimed to identify risk factors associated with the prognosis and mortality of non-HIV nontuberculous mycobacterial disease patients. This retrospective study was conducted at Peking Union Medical College Hospital. The electronic medical records in the hospital’s database from January 2013 to December 2022 were retrospectively reviewed. Relevant data, including clinical characteristics, laboratory findings, microbiological tests, treatments, and outcomes were collected and subjected to statistical analyses. The search identified 745 patients diagnosed with NTM infection, of whom 147 met the inclusion criteria. NTM pulmonary disease was the most commonly observed (n = 93; 63.3%), followed by disseminated infection (n = 43; 29.3%). The most frequent NTM species was Mycobacterium avium complex (55.8%), followed by Mycobacterium abscessus (21.2%). The incidence of Aspergillus and Pseudomonas aeruginosa infection was significantly higher in the NTM pulmonary disease group than in the disseminated NTM group. Cumulative mortality in the total patients was 24.49% at 5 years. High Charlson Comorbidity Index (CCI), high neutrophil-to-lymphocyte-ratio (NLR), haematological disease, and disseminated infection were identified as independent predictors of unfavourable outcomes. The area under the curve (AUC) values for NLR and neutrophil-to-monocyte-plus-lymphocyte-ratio (NMLR) were 0.751 and 0.763 with optimal cut-off values of 9.50 and 3.83, respectively, for prediction of mortality in patients with NTM disease. |
| format | Article |
| id | doaj-art-19a090be374140858d99194135632f7f |
| institution | Kabale University |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-19a090be374140858d99194135632f7f2025-02-03T14:03:20ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2025.2459313Clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infectionJinjing Chai0Sujie Zhang1Chong Ma2Qimin Mei3Tao Liu4Jihai Liu5Yecheng Liu6Huadong Zhu7Emergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEmergency Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaEmergency Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaEmergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, ChinaEmergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEmergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaEmergency Department, The State Key Laboratory for Complex, Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaRecently, the incidence and prevalence of NTM have been increasing nationwide in many countries. This study aimed to identify risk factors associated with the prognosis and mortality of non-HIV nontuberculous mycobacterial disease patients. This retrospective study was conducted at Peking Union Medical College Hospital. The electronic medical records in the hospital’s database from January 2013 to December 2022 were retrospectively reviewed. Relevant data, including clinical characteristics, laboratory findings, microbiological tests, treatments, and outcomes were collected and subjected to statistical analyses. The search identified 745 patients diagnosed with NTM infection, of whom 147 met the inclusion criteria. NTM pulmonary disease was the most commonly observed (n = 93; 63.3%), followed by disseminated infection (n = 43; 29.3%). The most frequent NTM species was Mycobacterium avium complex (55.8%), followed by Mycobacterium abscessus (21.2%). The incidence of Aspergillus and Pseudomonas aeruginosa infection was significantly higher in the NTM pulmonary disease group than in the disseminated NTM group. Cumulative mortality in the total patients was 24.49% at 5 years. High Charlson Comorbidity Index (CCI), high neutrophil-to-lymphocyte-ratio (NLR), haematological disease, and disseminated infection were identified as independent predictors of unfavourable outcomes. The area under the curve (AUC) values for NLR and neutrophil-to-monocyte-plus-lymphocyte-ratio (NMLR) were 0.751 and 0.763 with optimal cut-off values of 9.50 and 3.83, respectively, for prediction of mortality in patients with NTM disease.https://www.tandfonline.com/doi/10.1080/21505594.2025.2459313Nontuberculous mycobacteriamortalitycomorbidityrisk factorsprognosis |
| spellingShingle | Jinjing Chai Sujie Zhang Chong Ma Qimin Mei Tao Liu Jihai Liu Yecheng Liu Huadong Zhu Clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infection Virulence Nontuberculous mycobacteria mortality comorbidity risk factors prognosis |
| title | Clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infection |
| title_full | Clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infection |
| title_fullStr | Clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infection |
| title_full_unstemmed | Clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infection |
| title_short | Clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infection |
| title_sort | clinical analysis and risk factors associated with poor prognosis in nontuberculous mycobacterial infection |
| topic | Nontuberculous mycobacteria mortality comorbidity risk factors prognosis |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2025.2459313 |
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