Novel (±)-trans-β-lactam ureas: Synthesis, in silico and in vitro biological profiling

Novel (±)-trans-β-lactam ureas: Synthesis, in silico and in vitro biological profiling

A diastereomeric mixture of racemic 3-phthalimido-b-lactam 2a/2b was synthesized by the Staudinger reaction of carboxylic acid activated with 2-chloro-1-methylpyridinium iodide and imine 1. The amino group at the C3 position of the b-lactam ring was used for further structural upgrade. trans-b-lacta...

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Bibliographic Details
Main Authors: Jurin Mladenka, Stepanić Višnja, Bojanić Krunoslav, Vadlja Denis, Kontrec Darko, Dražić Tonko, Roje Marin
Format: Article
Language:English
Published: Sciendo 2024-03-01
Series:Acta Pharmaceutica
Subjects:
(±)-trans-b-lactam ureas
antiproliferative activity
in silico admet prediction
in silico biological profiling
Online Access:https://doi.org/10.2478/acph-2024-0008
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