Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives
The intratumoral microbiome plays a significant role in many cancers, such as lung, pancreatic, and colorectal cancer. Pancreatic cancer (PC) is one of the most lethal malignancies and is often diagnosed at advanced stages. <i>Fusobacterium nucleatum (Fn)</i>, an anaerobic Gram-negative...
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2024-12-01
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| author | Domenica Lucia D’Antonio Anna Zenoniani Samia Umme Adriano Piattelli Maria Cristina Curia |
| author_facet | Domenica Lucia D’Antonio Anna Zenoniani Samia Umme Adriano Piattelli Maria Cristina Curia |
| author_sort | Domenica Lucia D’Antonio |
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| description | The intratumoral microbiome plays a significant role in many cancers, such as lung, pancreatic, and colorectal cancer. Pancreatic cancer (PC) is one of the most lethal malignancies and is often diagnosed at advanced stages. <i>Fusobacterium nucleatum (Fn)</i>, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in several extra-oral human diseases and, lately, in pancreatic cancer progression and prognosis. It is now recognized as oncobacterium. <i>Fn</i> engages in pancreatic tumorigenesis and metastasis through multifaceted mechanisms, including immune response modulation, virulence factors, control of cell proliferation, intestinal metabolite interactions, DNA damage, and epithelial–mesenchymal transition. Additionally, compelling research suggests that <i>Fn</i> may exert detrimental effects on cancer treatment outcomes. This paper extends the perspective to pancreatic cancer associated with <i>Fn</i>. The central focus is to unravel the oncogenomic changes driven by <i>Fn in</i> colonization, initiation, and promotion of pancreatic cancer development. The presence of <i>Fusobacterium</i> species can be considered a prognostic marker of PC, and it is also correlated to chemoresistance. Furthermore, this review underscores the clinical research significance of <i>Fn</i> as a potential tumor biomarker and therapeutic target, offering a novel outlook on its applicability in cancer detection and prognostic assessment. It is thought that given the role of <i>Fn</i> in tumor formation and metastasis processes via its FadA, FapA, Fap2, and RadD, new therapies for tumor treatment targeting <i>Fn</i> will be developed. |
| format | Article |
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| institution | Kabale University |
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| language | English |
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| series | Pathogens |
| spelling | doaj-art-199a8e791a984ac6a2ea640cb2124ee32025-01-24T13:44:33ZengMDPI AGPathogens2076-08172024-12-01141210.3390/pathogens14010002Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future PerspectivesDomenica Lucia D’Antonio0Anna Zenoniani1Samia Umme2Adriano Piattelli3Maria Cristina Curia4Department of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini, 66100 Chieti, ItalyDepartment of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini, 66100 Chieti, ItalyDepartment of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini, 66100 Chieti, ItalySchool of Dentistry, Saint Camillus International University of Health and Medical Sciences (UniCamillus), 00131 Rome, ItalyDepartment of Medical, Oral and Biotechnological Sciences, “G. d’Annunzio” University of Chieti-Pescara, Via dei Vestini, 66100 Chieti, ItalyThe intratumoral microbiome plays a significant role in many cancers, such as lung, pancreatic, and colorectal cancer. Pancreatic cancer (PC) is one of the most lethal malignancies and is often diagnosed at advanced stages. <i>Fusobacterium nucleatum (Fn)</i>, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in several extra-oral human diseases and, lately, in pancreatic cancer progression and prognosis. It is now recognized as oncobacterium. <i>Fn</i> engages in pancreatic tumorigenesis and metastasis through multifaceted mechanisms, including immune response modulation, virulence factors, control of cell proliferation, intestinal metabolite interactions, DNA damage, and epithelial–mesenchymal transition. Additionally, compelling research suggests that <i>Fn</i> may exert detrimental effects on cancer treatment outcomes. This paper extends the perspective to pancreatic cancer associated with <i>Fn</i>. The central focus is to unravel the oncogenomic changes driven by <i>Fn in</i> colonization, initiation, and promotion of pancreatic cancer development. The presence of <i>Fusobacterium</i> species can be considered a prognostic marker of PC, and it is also correlated to chemoresistance. Furthermore, this review underscores the clinical research significance of <i>Fn</i> as a potential tumor biomarker and therapeutic target, offering a novel outlook on its applicability in cancer detection and prognostic assessment. It is thought that given the role of <i>Fn</i> in tumor formation and metastasis processes via its FadA, FapA, Fap2, and RadD, new therapies for tumor treatment targeting <i>Fn</i> will be developed.https://www.mdpi.com/2076-0817/14/1/2intratumoral microbiotadysbiosisfusobacterium nucleatumoncobacteriumpancreatic cancerPDAC |
| spellingShingle | Domenica Lucia D’Antonio Anna Zenoniani Samia Umme Adriano Piattelli Maria Cristina Curia Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives Pathogens intratumoral microbiota dysbiosis fusobacterium nucleatum oncobacterium pancreatic cancer PDAC |
| title | Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives |
| title_full | Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives |
| title_fullStr | Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives |
| title_full_unstemmed | Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives |
| title_short | Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives |
| title_sort | intratumoral i fusobacterium nucleatum i in pancreatic cancer current and future perspectives |
| topic | intratumoral microbiota dysbiosis fusobacterium nucleatum oncobacterium pancreatic cancer PDAC |
| url | https://www.mdpi.com/2076-0817/14/1/2 |
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