ANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIA
Parameters of lipid metabolism in the spectrum of blood serum are the most commonly used indicators in clinical practice. Their disturbances (dyslipidemia) are: elevated levels of total cholesterol and triglycerides, as well as changes of other parameters resulting from aberrations in lipoprotein sy...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-01-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/315 |
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| author | I. V. Nikolaev R. V. Mulyukova L. R. Kayumova E. V. Vorobievа V. Yu. Gorbunova |
| author_facet | I. V. Nikolaev R. V. Mulyukova L. R. Kayumova E. V. Vorobievа V. Yu. Gorbunova |
| author_sort | I. V. Nikolaev |
| collection | DOAJ |
| description | Parameters of lipid metabolism in the spectrum of blood serum are the most commonly used indicators in clinical practice. Their disturbances (dyslipidemia) are: elevated levels of total cholesterol and triglycerides, as well as changes of other parameters resulting from aberrations in lipoprotein synthesis, transport and cleavage. The clinical significance of metabolic disorders covered by the term dyslipidemia is associated primarily with high risks of cardiovascular diseases, diabetes mellitus type 2, and obesity. Associations of certain SNPs (G-2548A in the promoter region of the leptin gene (LEP), A223G in exon 4 of the leptin receptor gene (LEPR), T495G in intron 8 in the lipoprotein lipase gene (LPL), and C34G in exon 8 of a nuclear receptor (PPARG)) with disturbed lipid metabolism have been investigated, and their cumulative contribution to the development of dyslipidemia is demonstrated. |
| format | Article |
| id | doaj-art-199650a6f870478da83df1b2ae564c0b |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-199650a6f870478da83df1b2ae564c0b2025-02-01T09:58:01ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592015-01-01184/2856866298ANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIAI. V. Nikolaev0R. V. Mulyukova1L. R. Kayumova2E. V. Vorobievа3V. Yu. Gorbunova4Akmulla Bashkir State Pedagogical University, Ufa, RussiaAkmulla Bashkir State Pedagogical University, Ufa, RussiaAkmulla Bashkir State Pedagogical University, Ufa, RussiaAkmulla Bashkir State Pedagogical University, Ufa, RussiaAkmulla Bashkir State Pedagogical University, Ufa, RussiaParameters of lipid metabolism in the spectrum of blood serum are the most commonly used indicators in clinical practice. Their disturbances (dyslipidemia) are: elevated levels of total cholesterol and triglycerides, as well as changes of other parameters resulting from aberrations in lipoprotein synthesis, transport and cleavage. The clinical significance of metabolic disorders covered by the term dyslipidemia is associated primarily with high risks of cardiovascular diseases, diabetes mellitus type 2, and obesity. Associations of certain SNPs (G-2548A in the promoter region of the leptin gene (LEP), A223G in exon 4 of the leptin receptor gene (LEPR), T495G in intron 8 in the lipoprotein lipase gene (LPL), and C34G in exon 8 of a nuclear receptor (PPARG)) with disturbed lipid metabolism have been investigated, and their cumulative contribution to the development of dyslipidemia is demonstrated.https://vavilov.elpub.ru/jour/article/view/315dyslipidemiasingle-nucleotide polymorphismleptinleptin receptorlipoprotein lipasenuclear receptor |
| spellingShingle | I. V. Nikolaev R. V. Mulyukova L. R. Kayumova E. V. Vorobievа V. Yu. Gorbunova ANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIA Вавиловский журнал генетики и селекции dyslipidemia single-nucleotide polymorphism leptin leptin receptor lipoprotein lipase nuclear receptor |
| title | ANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIA |
| title_full | ANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIA |
| title_fullStr | ANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIA |
| title_full_unstemmed | ANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIA |
| title_short | ANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIA |
| title_sort | analysis of the interaction of lipid metabolism alleles in dyslipidemia |
| topic | dyslipidemia single-nucleotide polymorphism leptin leptin receptor lipoprotein lipase nuclear receptor |
| url | https://vavilov.elpub.ru/jour/article/view/315 |
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