ANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIA
Parameters of lipid metabolism in the spectrum of blood serum are the most commonly used indicators in clinical practice. Their disturbances (dyslipidemia) are: elevated levels of total cholesterol and triglycerides, as well as changes of other parameters resulting from aberrations in lipoprotein sy...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-01-01
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| Series: | Вавиловский журнал генетики и селекции |
| Subjects: | |
| Online Access: | https://vavilov.elpub.ru/jour/article/view/315 |
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| Summary: | Parameters of lipid metabolism in the spectrum of blood serum are the most commonly used indicators in clinical practice. Their disturbances (dyslipidemia) are: elevated levels of total cholesterol and triglycerides, as well as changes of other parameters resulting from aberrations in lipoprotein synthesis, transport and cleavage. The clinical significance of metabolic disorders covered by the term dyslipidemia is associated primarily with high risks of cardiovascular diseases, diabetes mellitus type 2, and obesity. Associations of certain SNPs (G-2548A in the promoter region of the leptin gene (LEP), A223G in exon 4 of the leptin receptor gene (LEPR), T495G in intron 8 in the lipoprotein lipase gene (LPL), and C34G in exon 8 of a nuclear receptor (PPARG)) with disturbed lipid metabolism have been investigated, and their cumulative contribution to the development of dyslipidemia is demonstrated. |
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| ISSN: | 2500-3259 |