Neurologic Complications Associated with Sjögren’s Disease: Case Reports and Modern Pathogenic Dilemma
Objectives. Sjögren’s syndrome (SS) may be complicated by some neurological manifestations, generally sensory polyneuropathy. Furthermore, involvement of cranial nerves was described as rare complications of SS. Methods. We reported 2 cases: the first one was a 40-year-old woman who developed neurit...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/590292 |
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| author | Michele Colaci Giulia Cassone Andreina Manfredi Marco Sebastiani Dilia Giuggioli Clodoveo Ferri |
| author_facet | Michele Colaci Giulia Cassone Andreina Manfredi Marco Sebastiani Dilia Giuggioli Clodoveo Ferri |
| author_sort | Michele Colaci |
| collection | DOAJ |
| description | Objectives. Sjögren’s syndrome (SS) may be complicated by some neurological manifestations, generally sensory polyneuropathy. Furthermore, involvement of cranial nerves was described as rare complications of SS. Methods. We reported 2 cases: the first one was a 40-year-old woman who developed neuritis of the left optic nerve as presenting symptom few years before the diagnosis of SS; the second was a 54-year-old woman who presented a paralysis of the right phrenic nerve 7 years after the SS onset. An exhaustive review of the literature on patients with cranial or phrenic nerve involvements was also carried out. Results. To the best of our knowledge, our second case represents the first observation of SS-associated phrenic nerve mononeuritis, while optic neuritis represents the most frequent cranial nerve involvement detectable in this connective tissue disease. Trigeminal neuropathy is also frequently reported, whereas neuritis involving the other cranial nerves is quite rare. Conclusions. Cranial nerve injury is a harmful complication of SS, even if less commonly recorded compared to peripheral neuropathy. Neurological manifestations may precede the clinical onset of SS; therefore, in patients with apparently isolated cranial nerve involvement, a correct diagnosis of the underlying SS is often delayed or overlooked entirely; in these instances, standard clinicoserological assessment is recommendable. |
| format | Article |
| id | doaj-art-197c7eb0a8e04558aff012ebda3f8c62 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-197c7eb0a8e04558aff012ebda3f8c622025-02-03T06:01:18ZengWileyCase Reports in Neurological Medicine2090-66682090-66762014-01-01201410.1155/2014/590292590292Neurologic Complications Associated with Sjögren’s Disease: Case Reports and Modern Pathogenic DilemmaMichele Colaci0Giulia Cassone1Andreina Manfredi2Marco Sebastiani3Dilia Giuggioli4Clodoveo Ferri5Chair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyChair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyChair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyChair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyChair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyChair and Rheumatology Unit, Medical School, Azienda Ospedaliero-Universitaria, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo 71, 41100 Modena, ItalyObjectives. Sjögren’s syndrome (SS) may be complicated by some neurological manifestations, generally sensory polyneuropathy. Furthermore, involvement of cranial nerves was described as rare complications of SS. Methods. We reported 2 cases: the first one was a 40-year-old woman who developed neuritis of the left optic nerve as presenting symptom few years before the diagnosis of SS; the second was a 54-year-old woman who presented a paralysis of the right phrenic nerve 7 years after the SS onset. An exhaustive review of the literature on patients with cranial or phrenic nerve involvements was also carried out. Results. To the best of our knowledge, our second case represents the first observation of SS-associated phrenic nerve mononeuritis, while optic neuritis represents the most frequent cranial nerve involvement detectable in this connective tissue disease. Trigeminal neuropathy is also frequently reported, whereas neuritis involving the other cranial nerves is quite rare. Conclusions. Cranial nerve injury is a harmful complication of SS, even if less commonly recorded compared to peripheral neuropathy. Neurological manifestations may precede the clinical onset of SS; therefore, in patients with apparently isolated cranial nerve involvement, a correct diagnosis of the underlying SS is often delayed or overlooked entirely; in these instances, standard clinicoserological assessment is recommendable.http://dx.doi.org/10.1155/2014/590292 |
| spellingShingle | Michele Colaci Giulia Cassone Andreina Manfredi Marco Sebastiani Dilia Giuggioli Clodoveo Ferri Neurologic Complications Associated with Sjögren’s Disease: Case Reports and Modern Pathogenic Dilemma Case Reports in Neurological Medicine |
| title | Neurologic Complications Associated with Sjögren’s Disease: Case Reports and Modern Pathogenic Dilemma |
| title_full | Neurologic Complications Associated with Sjögren’s Disease: Case Reports and Modern Pathogenic Dilemma |
| title_fullStr | Neurologic Complications Associated with Sjögren’s Disease: Case Reports and Modern Pathogenic Dilemma |
| title_full_unstemmed | Neurologic Complications Associated with Sjögren’s Disease: Case Reports and Modern Pathogenic Dilemma |
| title_short | Neurologic Complications Associated with Sjögren’s Disease: Case Reports and Modern Pathogenic Dilemma |
| title_sort | neurologic complications associated with sjogren s disease case reports and modern pathogenic dilemma |
| url | http://dx.doi.org/10.1155/2014/590292 |
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