Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs
The performance of the cerebral state index (CSI) in reflecting different levels of isoflurane anaesthesia was evaluated in ten cats subjected to four end-tidal isoflurane concentrations (EtIso), each maintained for 15 minutes (0.8%, 1.2%, 1.6%, or 2.0% EtIso). The CSI, hemodynamic data, ocular refl...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2014/481460 |
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| author | Joana R. Sousa Lénio Ribeiro Aura Silva David A. Ferreira |
| author_facet | Joana R. Sousa Lénio Ribeiro Aura Silva David A. Ferreira |
| author_sort | Joana R. Sousa |
| collection | DOAJ |
| description | The performance of the cerebral state index (CSI) in reflecting different levels of isoflurane anaesthesia was evaluated in ten cats subjected to four end-tidal isoflurane concentrations (EtIso), each maintained for 15 minutes (0.8%, 1.2%, 1.6%, or 2.0% EtIso). The CSI, hemodynamic data, ocular reflexes, and eye position were recorded for each EtIso concentration. Pharmacodynamic analysis of CSI with EtIso was performed, as well as prediction probability analysis with a clinical scale based on the eye reflexes. The CSI values showed great variability. Between all parameters, burst suppression ratio showed the better fitting with the sigmoidal concentration-effect model (R2=0.93) followed by CSI (R2=0.82) and electromyographic activity (R2=0.79). EtIso was the variable with better prediction of the clinical scale of anaesthesia (prediction probability value of 0.94). Although the CSI values decrease with increasing isoflurane concentrations, the huge variability in CSI values may be a strong limitation for its use in cats and it seems to be no better than EtIso as a predictor of clinical signs. |
| format | Article |
| id | doaj-art-197adca901854f1fbd95e853e8fff826 |
| institution | Kabale University |
| issn | 2090-8113 2042-0048 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-197adca901854f1fbd95e853e8fff8262025-02-03T05:52:06ZengWileyVeterinary Medicine International2090-81132042-00482014-01-01201410.1155/2014/481460481460Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical SignsJoana R. Sousa0Lénio Ribeiro1Aura Silva2David A. Ferreira3Centro de Investigação em Ciências Veterinárias, Faculdade de Medicina Veterinária, Universidade Lusófona de Humanidades e Tecnologia, Campo Grande 376, 1749-024 Lisboa, PortugalHospital Veterinário do Porto, Travessa Silva Porto 174, 4250-475 Porto, PortugalREQUIMTE, Laboratório de Toxicologia, Faculdade de Farmácia da Universidade do Porto, Rua de Jorge Viterbo Ferreira No. 228, 4050-313 Porto, PortugalCentro de Investigação em Ciências Veterinárias, Faculdade de Medicina Veterinária, Universidade Lusófona de Humanidades e Tecnologia, Campo Grande 376, 1749-024 Lisboa, PortugalThe performance of the cerebral state index (CSI) in reflecting different levels of isoflurane anaesthesia was evaluated in ten cats subjected to four end-tidal isoflurane concentrations (EtIso), each maintained for 15 minutes (0.8%, 1.2%, 1.6%, or 2.0% EtIso). The CSI, hemodynamic data, ocular reflexes, and eye position were recorded for each EtIso concentration. Pharmacodynamic analysis of CSI with EtIso was performed, as well as prediction probability analysis with a clinical scale based on the eye reflexes. The CSI values showed great variability. Between all parameters, burst suppression ratio showed the better fitting with the sigmoidal concentration-effect model (R2=0.93) followed by CSI (R2=0.82) and electromyographic activity (R2=0.79). EtIso was the variable with better prediction of the clinical scale of anaesthesia (prediction probability value of 0.94). Although the CSI values decrease with increasing isoflurane concentrations, the huge variability in CSI values may be a strong limitation for its use in cats and it seems to be no better than EtIso as a predictor of clinical signs.http://dx.doi.org/10.1155/2014/481460 |
| spellingShingle | Joana R. Sousa Lénio Ribeiro Aura Silva David A. Ferreira Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs Veterinary Medicine International |
| title | Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs |
| title_full | Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs |
| title_fullStr | Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs |
| title_full_unstemmed | Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs |
| title_short | Evaluation of the Cerebral State Index in Cats under Isoflurane Anaesthesia: Dose-Effect Relationship and Prediction of Clinical Signs |
| title_sort | evaluation of the cerebral state index in cats under isoflurane anaesthesia dose effect relationship and prediction of clinical signs |
| url | http://dx.doi.org/10.1155/2014/481460 |
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