Integrin Trafficking and Tumor Progression
Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent studies highlight the importance of integrin trafficking, endoc...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2012/516789 |
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| _version_ | 1832549491343884288 |
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| author | Sejeong Shin Laura Wolgamott Sang-Oh Yoon |
| author_facet | Sejeong Shin Laura Wolgamott Sang-Oh Yoon |
| author_sort | Sejeong Shin |
| collection | DOAJ |
| description | Integrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent studies highlight the importance of integrin trafficking, endocytosis and recycling, for the functions of integrins in cancer cells. Understanding the molecular mechanisms of integrin trafficking is pivotal for understanding tumor progression and for the development of anticancer drugs. |
| format | Article |
| id | doaj-art-1976e7c4f702471999fd819fdae87749 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-1976e7c4f702471999fd819fdae877492025-02-03T06:11:06ZengWileyInternational Journal of Cell Biology1687-88761687-88842012-01-01201210.1155/2012/516789516789Integrin Trafficking and Tumor ProgressionSejeong Shin0Laura Wolgamott1Sang-Oh Yoon2Department of Cancer and Cell Biology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Cancer and Cell Biology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USADepartment of Cancer and Cell Biology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USAIntegrins are major mediators of cancer cell adhesion to extracellular matrix. Through this interaction, integrins play critical roles in cell migration, invasion, metastasis, and resistance to apoptosis during tumor progression. Recent studies highlight the importance of integrin trafficking, endocytosis and recycling, for the functions of integrins in cancer cells. Understanding the molecular mechanisms of integrin trafficking is pivotal for understanding tumor progression and for the development of anticancer drugs.http://dx.doi.org/10.1155/2012/516789 |
| spellingShingle | Sejeong Shin Laura Wolgamott Sang-Oh Yoon Integrin Trafficking and Tumor Progression International Journal of Cell Biology |
| title | Integrin Trafficking and Tumor Progression |
| title_full | Integrin Trafficking and Tumor Progression |
| title_fullStr | Integrin Trafficking and Tumor Progression |
| title_full_unstemmed | Integrin Trafficking and Tumor Progression |
| title_short | Integrin Trafficking and Tumor Progression |
| title_sort | integrin trafficking and tumor progression |
| url | http://dx.doi.org/10.1155/2012/516789 |
| work_keys_str_mv | AT sejeongshin integrintraffickingandtumorprogression AT laurawolgamott integrintraffickingandtumorprogression AT sangohyoon integrintraffickingandtumorprogression |