The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock
Severe sepsis and septic shock are a primary cause of death in patients in intensive care unit (ICU). Investigations upon genetic susceptibility profile to systemic complications during severe infections are a field of increasing scientific interest. Particularly when adaptive immune system is compr...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/625803 |
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| author | Gennaro De Pascale Salvatore Lucio Cutuli Mariano Alberto Pennisi Massimo Antonelli |
| author_facet | Gennaro De Pascale Salvatore Lucio Cutuli Mariano Alberto Pennisi Massimo Antonelli |
| author_sort | Gennaro De Pascale |
| collection | DOAJ |
| description | Severe sepsis and septic shock are a primary cause of death in patients in intensive care unit (ICU). Investigations upon genetic susceptibility profile to systemic complications during severe infections are a field of increasing scientific interest. Particularly when adaptive immune system is compromised or immature, innate immunity plays a key role in the immediate defense against invasive pathogens. Mannose-binding lectin (MBL) is a serum protein that recognizes a wide range of pathogenic microorganisms and activates complement cascade via the antibody-independent pathway. More than 30% of humans harbor mutations in MBL gene (MBL2) resulting in reduced plasmatic levels and activity. Increased risk of infection acquisition has been largely documented in MBL-deficient patients, but the real impact of this form of innate immunosuppression upon clinical outcome is not clear. In critically ill patients higher incidence and worse prognosis of severe sepsis/septic shock appear to be associated with low-producers haplotypes. However an excess of MBL activation might be also harmful due to the possibility of an unbalanced proinflammatory response and an additional host injury. Strategies of replacement therapies in critically ill patients with severe infections are under investigation but still far to be applied in clinical practice. |
| format | Article |
| id | doaj-art-1975e73f7db1490591c263652c554a7c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1975e73f7db1490591c263652c554a7c2025-02-03T01:02:52ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/625803625803The Role of Mannose-Binding Lectin in Severe Sepsis and Septic ShockGennaro De Pascale0Salvatore Lucio Cutuli1Mariano Alberto Pennisi2Massimo Antonelli3Department of Anesthesiology and Intensive Care, Catholic University of the Sacred Heart, Agostino Gemelli Hospital, 00168 Rome, ItalyDepartment of Anesthesiology and Intensive Care, Catholic University of the Sacred Heart, Agostino Gemelli Hospital, 00168 Rome, ItalyDepartment of Anesthesiology and Intensive Care, Catholic University of the Sacred Heart, Agostino Gemelli Hospital, 00168 Rome, ItalyDepartment of Anesthesiology and Intensive Care, Catholic University of the Sacred Heart, Agostino Gemelli Hospital, 00168 Rome, ItalySevere sepsis and septic shock are a primary cause of death in patients in intensive care unit (ICU). Investigations upon genetic susceptibility profile to systemic complications during severe infections are a field of increasing scientific interest. Particularly when adaptive immune system is compromised or immature, innate immunity plays a key role in the immediate defense against invasive pathogens. Mannose-binding lectin (MBL) is a serum protein that recognizes a wide range of pathogenic microorganisms and activates complement cascade via the antibody-independent pathway. More than 30% of humans harbor mutations in MBL gene (MBL2) resulting in reduced plasmatic levels and activity. Increased risk of infection acquisition has been largely documented in MBL-deficient patients, but the real impact of this form of innate immunosuppression upon clinical outcome is not clear. In critically ill patients higher incidence and worse prognosis of severe sepsis/septic shock appear to be associated with low-producers haplotypes. However an excess of MBL activation might be also harmful due to the possibility of an unbalanced proinflammatory response and an additional host injury. Strategies of replacement therapies in critically ill patients with severe infections are under investigation but still far to be applied in clinical practice.http://dx.doi.org/10.1155/2013/625803 |
| spellingShingle | Gennaro De Pascale Salvatore Lucio Cutuli Mariano Alberto Pennisi Massimo Antonelli The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock Mediators of Inflammation |
| title | The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock |
| title_full | The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock |
| title_fullStr | The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock |
| title_full_unstemmed | The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock |
| title_short | The Role of Mannose-Binding Lectin in Severe Sepsis and Septic Shock |
| title_sort | role of mannose binding lectin in severe sepsis and septic shock |
| url | http://dx.doi.org/10.1155/2013/625803 |
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