Clinical Molecular Immunohistochemistry Mismatch Repair Mutations in Lynch Syndrome in Patients Under 50 Years: A Systematic Review

Clinical Molecular Immunohistochemistry Mismatch Repair Mutations in Lynch Syndrome in Patients Under 50 Years: A Systematic Review

<b>Background and Objectives</b>: Lynch syndrome (LS), an autosomal dominant condition arising from germline mutations in mismatch repair (MMR) genes, is a major cause of hereditary early-onset colorectal cancer (CRC). Although patients diagnosed before age 50 represent a critical subgro...

Full description

Saved in:
Bibliographic Details
Main Authors: Bogdan Adrian Manta, Adrian Cosmin Ilie, Felicia Marc, Daciana Nistor, Patricia Octavia Mazilu, Claudia Borza
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomedicines
Subjects:
Lynch syndrome
mismatch repair deficiency
immunohistochemistry
early-onset colorectal cancer
molecular testing
Online Access:https://www.mdpi.com/2227-9059/13/5/1062
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2227-9059/13/5/1062

Similar Items