Trends and Disparities in the Burden of Chronic Kidney Disease due to Type 2 Diabetes in China From 1990 to 2021: A Population‐Based Study
ABSTRACT Background This study analyzes the trends in the burden of chronic kidney disease due to type 2 diabetes (CKD‐T2D) in China from 1990 to 2021, evaluates variations in risk factors, and projects the disease burden through 2036. Method Estimates of prevalence, incidence, mortality, and disabi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-04-01
|
| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.70084 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849310482378260480 |
|---|---|
| author | Yifei Wang Shiya Gu Zhixuan Xie Zhiyong Xu Wenfang He Yexiang Chen Juan Jin Qiang He |
| author_facet | Yifei Wang Shiya Gu Zhixuan Xie Zhiyong Xu Wenfang He Yexiang Chen Juan Jin Qiang He |
| author_sort | Yifei Wang |
| collection | DOAJ |
| description | ABSTRACT Background This study analyzes the trends in the burden of chronic kidney disease due to type 2 diabetes (CKD‐T2D) in China from 1990 to 2021, evaluates variations in risk factors, and projects the disease burden through 2036. Method Estimates of prevalence, incidence, mortality, and disability‐adjusted life years (DALYs) for CKD‐T2D were retrieved along with their 95% uncertainty intervals (UIs). Age‐period‐cohort analysis was used to assess burden trends from 1990 to 2021, identify risk factor population attributable fractions (PAFs), and project the burden through 2036. Results In 2021, there were 20 911 520 CKD‐T2D cases in China, with an age‐standardized prevalence rate (ASPR) of 1053.92 per 100 000, an incidence rate (ASIR) of 23.07, an age‐standardized mortality rate (ASMR) of 5.72, and an age‐standardized DALY rate (ASDR) of 122.15. Although the overall burden showed a slow decline from 1990 to 2021, incidence continued to rise. The 2021 data revealed a marked age effect, with the burden rising with age. Period effects also contributed to an increased risk, with metabolic risk factors such as high fasting plasma glucose and BMI contributing the most. Projections suggest a decline in mortality and DALYs by 2036, while incidence will keep increasing. Conclusion Despite declines in ASMR and ASDR, CKD‐T2D incidence and cases continue to rise, especially among males and the elderly. This increasing burden is driven by aging and metabolic risk factors. Early screening, education, and risk management are essential for addressing CKD‐T2D in China. |
| format | Article |
| id | doaj-art-195b1d3336864f969b7385921ec61bf9 |
| institution | Kabale University |
| issn | 1753-0393 1753-0407 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj-art-195b1d3336864f969b7385921ec61bf92025-08-20T03:53:42ZengWileyJournal of Diabetes1753-03931753-04072025-04-01174n/an/a10.1111/1753-0407.70084Trends and Disparities in the Burden of Chronic Kidney Disease due to Type 2 Diabetes in China From 1990 to 2021: A Population‐Based StudyYifei Wang0Shiya Gu1Zhixuan Xie2Zhiyong Xu3Wenfang He4Yexiang Chen5Juan Jin6Qiang He7Department of Nephrology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou Zhejiang ChinaDepartment of Nephrology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou Zhejiang ChinaInstitute of Chronic Nephropathy Wenzhou Medical University Wenzhou Zhejiang ChinaDepartment of Nephrology, XianJu People's Hospital, Zhejiang Southeast Campus of Zhejiang Provincial People's Hospital Affiliated Xianju's Hospital, Hangzhou Medical College Xianju Zhejiang ChinaDepartment of Nephrology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou Zhejiang ChinaThe Third Clinical Medical College Zhejiang Chinese Medical University Hangzhou Zhejiang ChinaDepartment of Nephrology The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) Hangzhou Zhejiang ChinaInstitute of Chronic Nephropathy Wenzhou Medical University Wenzhou Zhejiang ChinaABSTRACT Background This study analyzes the trends in the burden of chronic kidney disease due to type 2 diabetes (CKD‐T2D) in China from 1990 to 2021, evaluates variations in risk factors, and projects the disease burden through 2036. Method Estimates of prevalence, incidence, mortality, and disability‐adjusted life years (DALYs) for CKD‐T2D were retrieved along with their 95% uncertainty intervals (UIs). Age‐period‐cohort analysis was used to assess burden trends from 1990 to 2021, identify risk factor population attributable fractions (PAFs), and project the burden through 2036. Results In 2021, there were 20 911 520 CKD‐T2D cases in China, with an age‐standardized prevalence rate (ASPR) of 1053.92 per 100 000, an incidence rate (ASIR) of 23.07, an age‐standardized mortality rate (ASMR) of 5.72, and an age‐standardized DALY rate (ASDR) of 122.15. Although the overall burden showed a slow decline from 1990 to 2021, incidence continued to rise. The 2021 data revealed a marked age effect, with the burden rising with age. Period effects also contributed to an increased risk, with metabolic risk factors such as high fasting plasma glucose and BMI contributing the most. Projections suggest a decline in mortality and DALYs by 2036, while incidence will keep increasing. Conclusion Despite declines in ASMR and ASDR, CKD‐T2D incidence and cases continue to rise, especially among males and the elderly. This increasing burden is driven by aging and metabolic risk factors. Early screening, education, and risk management are essential for addressing CKD‐T2D in China.https://doi.org/10.1111/1753-0407.70084Chinachronic kidney disease due to type 2 diabetes mellitusdisease burdenrisk factorstrends |
| spellingShingle | Yifei Wang Shiya Gu Zhixuan Xie Zhiyong Xu Wenfang He Yexiang Chen Juan Jin Qiang He Trends and Disparities in the Burden of Chronic Kidney Disease due to Type 2 Diabetes in China From 1990 to 2021: A Population‐Based Study Journal of Diabetes China chronic kidney disease due to type 2 diabetes mellitus disease burden risk factors trends |
| title | Trends and Disparities in the Burden of Chronic Kidney Disease due to Type 2 Diabetes in China From 1990 to 2021: A Population‐Based Study |
| title_full | Trends and Disparities in the Burden of Chronic Kidney Disease due to Type 2 Diabetes in China From 1990 to 2021: A Population‐Based Study |
| title_fullStr | Trends and Disparities in the Burden of Chronic Kidney Disease due to Type 2 Diabetes in China From 1990 to 2021: A Population‐Based Study |
| title_full_unstemmed | Trends and Disparities in the Burden of Chronic Kidney Disease due to Type 2 Diabetes in China From 1990 to 2021: A Population‐Based Study |
| title_short | Trends and Disparities in the Burden of Chronic Kidney Disease due to Type 2 Diabetes in China From 1990 to 2021: A Population‐Based Study |
| title_sort | trends and disparities in the burden of chronic kidney disease due to type 2 diabetes in china from 1990 to 2021 a population based study |
| topic | China chronic kidney disease due to type 2 diabetes mellitus disease burden risk factors trends |
| url | https://doi.org/10.1111/1753-0407.70084 |
| work_keys_str_mv | AT yifeiwang trendsanddisparitiesintheburdenofchronickidneydiseaseduetotype2diabetesinchinafrom1990to2021apopulationbasedstudy AT shiyagu trendsanddisparitiesintheburdenofchronickidneydiseaseduetotype2diabetesinchinafrom1990to2021apopulationbasedstudy AT zhixuanxie trendsanddisparitiesintheburdenofchronickidneydiseaseduetotype2diabetesinchinafrom1990to2021apopulationbasedstudy AT zhiyongxu trendsanddisparitiesintheburdenofchronickidneydiseaseduetotype2diabetesinchinafrom1990to2021apopulationbasedstudy AT wenfanghe trendsanddisparitiesintheburdenofchronickidneydiseaseduetotype2diabetesinchinafrom1990to2021apopulationbasedstudy AT yexiangchen trendsanddisparitiesintheburdenofchronickidneydiseaseduetotype2diabetesinchinafrom1990to2021apopulationbasedstudy AT juanjin trendsanddisparitiesintheburdenofchronickidneydiseaseduetotype2diabetesinchinafrom1990to2021apopulationbasedstudy AT qianghe trendsanddisparitiesintheburdenofchronickidneydiseaseduetotype2diabetesinchinafrom1990to2021apopulationbasedstudy |