Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children
Efficacy of short-course therapy with cephalosporins for treatment of group A β-hemolytic streptococcus (GABHS) pharyngitis is still controversial. Subjects were 226 children with a history of at least one episode of GABHS pharyngitis. Recurrence within the follow-up period (3 weeks after initiation...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2009/863608 |
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| author | Hideaki Kikuta Mutsuo Shibata Shuji Nakata Tatsuru Yamanaka Hiroshi Sakata Kouji Akizawa Kunihiko Kobayashi |
| author_facet | Hideaki Kikuta Mutsuo Shibata Shuji Nakata Tatsuru Yamanaka Hiroshi Sakata Kouji Akizawa Kunihiko Kobayashi |
| author_sort | Hideaki Kikuta |
| collection | DOAJ |
| description | Efficacy of short-course therapy with cephalosporins for treatment of group A β-hemolytic streptococcus (GABHS) pharyngitis is still controversial. Subjects were 226 children with a history of at least one episode of GABHS pharyngitis. Recurrence within the follow-up period (3 weeks after initiation of therapy) occurred in 7 of the 77 children in the 5-day treatment group and in 1 of the 149 children in the 10-day treatment group; the incidence of recurrence being significantly higher in the 5-day treatment group. Bacteriologic treatment failure (GABHS isolation without overt pharyngitis) at follow-up culture was observed in 7 of the 77 children in the 5-day treatment group and 17 of the 149 children in the 10-day treatment group. There was no statistical difference between the two groups. A 5-day course of oral cephalosporins is not always recommended for treatment of GABHS pharyngitis in children who have repeated episodes of pharyngitis. |
| format | Article |
| id | doaj-art-195a39e68c80414cbff8fea1a6689993 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-195a39e68c80414cbff8fea1a66899932025-02-03T01:26:06ZengWileyInternational Journal of Pediatrics1687-97401687-97592009-01-01200910.1155/2009/863608863608Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in ChildrenHideaki Kikuta0Mutsuo Shibata1Shuji Nakata2Tatsuru Yamanaka3Hiroshi Sakata4Kouji Akizawa5Kunihiko Kobayashi6Pediatric Clinic, Touei Hospital, N-41, E-16, Higashi-ku, Sapporo 007-0841, JapanPediatric Clinic, Touei Hospital, N-41, E-16, Higashi-ku, Sapporo 007-0841, JapanPediatric Clinic, Touei Hospital, N-41, E-16, Higashi-ku, Sapporo 007-0841, JapanPediatric Clinic, Touei Hospital, N-41, E-16, Higashi-ku, Sapporo 007-0841, JapanPediatric Clinic, Touei Hospital, N-41, E-16, Higashi-ku, Sapporo 007-0841, JapanPediatric Clinic, Touei Hospital, N-41, E-16, Higashi-ku, Sapporo 007-0841, JapanPediatric Clinic, Touei Hospital, N-41, E-16, Higashi-ku, Sapporo 007-0841, JapanEfficacy of short-course therapy with cephalosporins for treatment of group A β-hemolytic streptococcus (GABHS) pharyngitis is still controversial. Subjects were 226 children with a history of at least one episode of GABHS pharyngitis. Recurrence within the follow-up period (3 weeks after initiation of therapy) occurred in 7 of the 77 children in the 5-day treatment group and in 1 of the 149 children in the 10-day treatment group; the incidence of recurrence being significantly higher in the 5-day treatment group. Bacteriologic treatment failure (GABHS isolation without overt pharyngitis) at follow-up culture was observed in 7 of the 77 children in the 5-day treatment group and 17 of the 149 children in the 10-day treatment group. There was no statistical difference between the two groups. A 5-day course of oral cephalosporins is not always recommended for treatment of GABHS pharyngitis in children who have repeated episodes of pharyngitis.http://dx.doi.org/10.1155/2009/863608 |
| spellingShingle | Hideaki Kikuta Mutsuo Shibata Shuji Nakata Tatsuru Yamanaka Hiroshi Sakata Kouji Akizawa Kunihiko Kobayashi Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children International Journal of Pediatrics |
| title | Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
| title_full | Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
| title_fullStr | Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
| title_full_unstemmed | Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
| title_short | Comparative Study of 5-Day and 10-Day Cefditoren Pivoxil Treatments for Recurrent Group A β-Hemolytic Streptococcus pharyngitis in Children |
| title_sort | comparative study of 5 day and 10 day cefditoren pivoxil treatments for recurrent group a β hemolytic streptococcus pharyngitis in children |
| url | http://dx.doi.org/10.1155/2009/863608 |
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