Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results
Portal vein tumor thrombosis (PVTT) is a common complication of hepatocellular carcinoma (HCC) and has a negative impact on prognosis. This characteristic feature led to the rationale of the present trial designed to assess the efficacy and the safety of yttrium-90 glass-microsphere treatment for ad...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2013/827649 |
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| author | M. Pracht J. Edeline L. Lenoir M. Latournerie H. Mesbah O. Audrain Y. Rolland B. Clément J. L. Raoul E. Garin E. Boucher |
| author_facet | M. Pracht J. Edeline L. Lenoir M. Latournerie H. Mesbah O. Audrain Y. Rolland B. Clément J. L. Raoul E. Garin E. Boucher |
| author_sort | M. Pracht |
| collection | DOAJ |
| description | Portal vein tumor thrombosis (PVTT) is a common complication of hepatocellular carcinoma (HCC) and has a negative impact on prognosis. This characteristic feature led to the rationale of the present trial designed to assess the efficacy and the safety of yttrium-90 glass-microsphere treatment for advanced-stage lobar HCC with ipsilateral PVTT. 18 patients with unresectable lobar HCC and ipsilateral PVTT were treated in our institution with 90Y-microS radioembolization. Patients were evaluated every 3 to 6 months for response, survival, and toxicity. Mean follow-up was 13.0 months (2.2–50.6). Outcomes were: complete response (n=2), partial response (n=13), stable disease (n=1), and progressive disease (n=2) giving a disease control rate of 88.9%. Four patients were downstaged. Treating lobar hepatocellular carcinoma with ipsilateral portal vein thrombosis with yttrium-90 glass-microsphere radioembolization is safe and efficacious. Further clinical trials are warranted to confirm these results and to compare 90Y-microS with sorafenib, taking into account not only survival but also the possibility of secondary surgery for putative curative intention after downstaging. |
| format | Article |
| id | doaj-art-19479eb3a766450399ef75d352023e52 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-19479eb3a766450399ef75d352023e522025-02-03T01:27:37ZengWileyInternational Journal of Hepatology2090-34482090-34562013-01-01201310.1155/2013/827649827649Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary ResultsM. Pracht0J. Edeline1L. Lenoir2M. Latournerie3H. Mesbah4O. Audrain5Y. Rolland6B. Clément7J. L. Raoul8E. Garin9E. Boucher10Comprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, FranceComprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, FranceComprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, FranceComprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, FranceComprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, FranceComprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, FranceComprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, FranceUniversity of Rennes 1, 35043 Rennes, FranceDepartment of Digestive Oncology, Comprehensive Cancer Center Paoli Calmettes, 13273 Marseille, FranceComprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, FranceComprehensive Cancer Center Eugène Marquis, CS 44229, 35042 Rennes, FrancePortal vein tumor thrombosis (PVTT) is a common complication of hepatocellular carcinoma (HCC) and has a negative impact on prognosis. This characteristic feature led to the rationale of the present trial designed to assess the efficacy and the safety of yttrium-90 glass-microsphere treatment for advanced-stage lobar HCC with ipsilateral PVTT. 18 patients with unresectable lobar HCC and ipsilateral PVTT were treated in our institution with 90Y-microS radioembolization. Patients were evaluated every 3 to 6 months for response, survival, and toxicity. Mean follow-up was 13.0 months (2.2–50.6). Outcomes were: complete response (n=2), partial response (n=13), stable disease (n=1), and progressive disease (n=2) giving a disease control rate of 88.9%. Four patients were downstaged. Treating lobar hepatocellular carcinoma with ipsilateral portal vein thrombosis with yttrium-90 glass-microsphere radioembolization is safe and efficacious. Further clinical trials are warranted to confirm these results and to compare 90Y-microS with sorafenib, taking into account not only survival but also the possibility of secondary surgery for putative curative intention after downstaging.http://dx.doi.org/10.1155/2013/827649 |
| spellingShingle | M. Pracht J. Edeline L. Lenoir M. Latournerie H. Mesbah O. Audrain Y. Rolland B. Clément J. L. Raoul E. Garin E. Boucher Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results International Journal of Hepatology |
| title | Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results |
| title_full | Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results |
| title_fullStr | Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results |
| title_full_unstemmed | Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results |
| title_short | Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results |
| title_sort | lobar hepatocellular carcinoma with ipsilateral portal vein tumor thrombosis treated with yttrium 90 glass microsphere radioembolization preliminary results |
| url | http://dx.doi.org/10.1155/2013/827649 |
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