To Predict the Requirement of Pharmacotherapy by OGTT Glucose Levels in Women with GDM Classified by the IADPSG Criteria
The aim of this study was to assess the association between OGTT glucose levels and requirement of pharmacotherapy in GDM patients classified by the IADPSG criteria. This study included 203 GDM patients (108 managed with lifestyle modification and 95 requiring pharmacotherapy). Clinical risk factors...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/3243754 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558983694516224 |
|---|---|
| author | Gülen Yerlikaya Veronica Falcone Tina Stopp Martina Mittlböck Andrea Tura Peter Husslein Wolfgang Eppel Christian S. Göbl |
| author_facet | Gülen Yerlikaya Veronica Falcone Tina Stopp Martina Mittlböck Andrea Tura Peter Husslein Wolfgang Eppel Christian S. Göbl |
| author_sort | Gülen Yerlikaya |
| collection | DOAJ |
| description | The aim of this study was to assess the association between OGTT glucose levels and requirement of pharmacotherapy in GDM patients classified by the IADPSG criteria. This study included 203 GDM patients (108 managed with lifestyle modification and 95 requiring pharmacotherapy). Clinical risk factors and OGTT glucose concentrations at 0 (G0), 60 (G60), and 120 min (G120) were collected. OGTT glucose levels were significantly associated with the later requirement of pharmacotherapy (ROC-AUC: 71.1, 95% CI: 63.8–78.3). Also, the combination of clinical risk factors (age, BMI, parity, and pharmacotherapy in previous gestation) showed an acceptable predictive accuracy (ROC-AUC: 72.1, 95% CI: 65.0–79.2), which was further improved when glycemic parameters were added (ROC-AUC: 77.5, 95% CI: 71.5–83.9). Random forest analysis revealed the highest variable importance for G0, G60, and age. OGTT glucose measures in addition to clinical risk factors showed promising properties for risk stratification in GDM patients classified by the recently established IADPSG criteria. |
| format | Article |
| id | doaj-art-193d7a450f5449f9a2110c32736fa96a |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-193d7a450f5449f9a2110c32736fa96a2025-02-03T01:31:04ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/32437543243754To Predict the Requirement of Pharmacotherapy by OGTT Glucose Levels in Women with GDM Classified by the IADPSG CriteriaGülen Yerlikaya0Veronica Falcone1Tina Stopp2Martina Mittlböck3Andrea Tura4Peter Husslein5Wolfgang Eppel6Christian S. Göbl7Department of Obstetrics and Gynecology, Division of Obstetrics and Feto-Naternal Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics and Feto-Naternal Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics and Feto-Naternal Medicine, Medical University of Vienna, Vienna, AustriaCenter of Medical Statistics, Informatics, and Intelligent Systems, Section for Clinical Biometrics, Medical University of Vienna, Vienna, AustriaMetabolic Unit, Institute of Neuroscience, National Research Council, Padova, ItalyDepartment of Obstetrics and Gynecology, Division of Obstetrics and Feto-Naternal Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics and Feto-Naternal Medicine, Medical University of Vienna, Vienna, AustriaDepartment of Obstetrics and Gynecology, Division of Obstetrics and Feto-Naternal Medicine, Medical University of Vienna, Vienna, AustriaThe aim of this study was to assess the association between OGTT glucose levels and requirement of pharmacotherapy in GDM patients classified by the IADPSG criteria. This study included 203 GDM patients (108 managed with lifestyle modification and 95 requiring pharmacotherapy). Clinical risk factors and OGTT glucose concentrations at 0 (G0), 60 (G60), and 120 min (G120) were collected. OGTT glucose levels were significantly associated with the later requirement of pharmacotherapy (ROC-AUC: 71.1, 95% CI: 63.8–78.3). Also, the combination of clinical risk factors (age, BMI, parity, and pharmacotherapy in previous gestation) showed an acceptable predictive accuracy (ROC-AUC: 72.1, 95% CI: 65.0–79.2), which was further improved when glycemic parameters were added (ROC-AUC: 77.5, 95% CI: 71.5–83.9). Random forest analysis revealed the highest variable importance for G0, G60, and age. OGTT glucose measures in addition to clinical risk factors showed promising properties for risk stratification in GDM patients classified by the recently established IADPSG criteria.http://dx.doi.org/10.1155/2018/3243754 |
| spellingShingle | Gülen Yerlikaya Veronica Falcone Tina Stopp Martina Mittlböck Andrea Tura Peter Husslein Wolfgang Eppel Christian S. Göbl To Predict the Requirement of Pharmacotherapy by OGTT Glucose Levels in Women with GDM Classified by the IADPSG Criteria Journal of Diabetes Research |
| title | To Predict the Requirement of Pharmacotherapy by OGTT Glucose Levels in Women with GDM Classified by the IADPSG Criteria |
| title_full | To Predict the Requirement of Pharmacotherapy by OGTT Glucose Levels in Women with GDM Classified by the IADPSG Criteria |
| title_fullStr | To Predict the Requirement of Pharmacotherapy by OGTT Glucose Levels in Women with GDM Classified by the IADPSG Criteria |
| title_full_unstemmed | To Predict the Requirement of Pharmacotherapy by OGTT Glucose Levels in Women with GDM Classified by the IADPSG Criteria |
| title_short | To Predict the Requirement of Pharmacotherapy by OGTT Glucose Levels in Women with GDM Classified by the IADPSG Criteria |
| title_sort | to predict the requirement of pharmacotherapy by ogtt glucose levels in women with gdm classified by the iadpsg criteria |
| url | http://dx.doi.org/10.1155/2018/3243754 |
| work_keys_str_mv | AT gulenyerlikaya topredicttherequirementofpharmacotherapybyogttglucoselevelsinwomenwithgdmclassifiedbytheiadpsgcriteria AT veronicafalcone topredicttherequirementofpharmacotherapybyogttglucoselevelsinwomenwithgdmclassifiedbytheiadpsgcriteria AT tinastopp topredicttherequirementofpharmacotherapybyogttglucoselevelsinwomenwithgdmclassifiedbytheiadpsgcriteria AT martinamittlbock topredicttherequirementofpharmacotherapybyogttglucoselevelsinwomenwithgdmclassifiedbytheiadpsgcriteria AT andreatura topredicttherequirementofpharmacotherapybyogttglucoselevelsinwomenwithgdmclassifiedbytheiadpsgcriteria AT peterhusslein topredicttherequirementofpharmacotherapybyogttglucoselevelsinwomenwithgdmclassifiedbytheiadpsgcriteria AT wolfgangeppel topredicttherequirementofpharmacotherapybyogttglucoselevelsinwomenwithgdmclassifiedbytheiadpsgcriteria AT christiansgobl topredicttherequirementofpharmacotherapybyogttglucoselevelsinwomenwithgdmclassifiedbytheiadpsgcriteria |